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Anti-HGFR/c-Met Antibody (4V580) is a Rabbit antibody targeting HGFR/c-Met. Anti-HGFR/c-Met Antibody (4V580) can be used in FCM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μL | $92 | 7-10 days | |
100 μL | $269 | 7-10 days |
Description | Anti-HGFR/c-Met Antibody (4V580) is a Rabbit antibody targeting HGFR/c-Met. Anti-HGFR/c-Met Antibody (4V580) can be used in FCM. |
Alias | MET proto-oncogene, receptor tyrosine kinase |
Ig Type | Monoclonal Rabbit IgG |
Clone | 4V580 |
Reactivity | Human |
Verified Activity | Flow cytometric analysis of Human C-Met(HGFR) expression on HepG2 cells. Cells were stained with purified anti-Human C-Met(HGFR), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
Application | FCM |
Recommended Dose | FCM: 1:25-1:100 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human c-Met / HGFR (rh c-Met / HGFR; TMPY-01296; NP_000236.2; Met1-Thr932). |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
Conjucates | Unconjugated |
Others Formats | APC/FITC/PE |
Antibody Types Available | 4 |
Immunogen | Recombinant Human c-Met / HGFR protein (TMPY-01296) |
Antigen Species | Human |
Biology Area | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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