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Cyclapolin 9

Name: Cyclapolin 9
Brand: TargetMol
SKU: T22700
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22700Cas No. 40533-25-3

Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.

Cyclapolin 9

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Purity: 99.5%

Catalog No. T22700Cas No. 40533-25-3

Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$93	-	In Stock
5 mg	$228	-	In Stock
10 mg	$355	-	In Stock
25 mg	$569	-	In Stock
50 mg	$786	-	In Stock
100 mg	$1,070	-	In Stock
500 mg	$2,150	-	In Stock
1 mL x 10 mM (in DMSO)	$253	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.5%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.
Targets&IC50	PLK1:500 nM
In vitro	Reducing electric field stimulation (EFS)-induced contractions of prostate strips, Cyclapolin 9 (3 μM) has the ability to inhibit α1-adrenergic smooth muscle contraction in the human prostate[1]

Chemical Properties

Molecular Weight	307.21
Formula	C₉H₄F₃N₃O₄S
Cas No.	40533-25-3
Smiles	NC(=O)c1sc2c(cc(cc2[n+]1[O-])C(F)(F)F)[N+]([O-])=O
Relative Density.	1.96 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 10 mg/mL (32.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2551 mL	16.2755 mL	32.5510 mL	162.7551 mL
5 mM	0.6510 mL	3.2551 mL	6.5102 mL	32.5510 mL
10 mM	0.3255 mL	1.6276 mL	3.2551 mL	16.2755 mL
20 mM	0.1628 mL	0.8138 mL	1.6276 mL	8.1378 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc