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Cyclapolin 9

Name: Cyclapolin 9
Brand: TargetMol
SKU: T22700
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22700Cas No. 40533-25-3

Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.

Cyclapolin 9

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Purity: 99.64%

Catalog No. T22700Cas No. 40533-25-3

Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$93	-	In Stock
5 mg	$228	-	In Stock
10 mg	$355	-	In Stock
25 mg	$569	-	In Stock
50 mg	$786	-	In Stock
100 mg	$1,070	-	In Stock
500 mg	$2,150	-	In Stock
1 mL x 10 mM (in DMSO)	$253	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.64%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases.
Targets&IC50	PLK1:500 nM
In vitro	Reducing electric field stimulation (EFS)-induced contractions of prostate strips, Cyclapolin 9 (3 μM) has the ability to inhibit α1-adrenergic smooth muscle contraction in the human prostate[1]

Chemical Properties

Molecular Weight	307.21
Formula	C₉H₄F₃N₃O₄S
Cas No.	40533-25-3
Smiles	NC(=O)c1sc2c(cc(cc2[n+]1[O-])C(F)(F)F)[N+]([O-])=O
Relative Density.	1.96 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 10 mg/mL (32.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2551 mL	16.2755 mL	32.5510 mL	162.7551 mL
5 mM	0.6510 mL	3.2551 mL	6.5102 mL	32.5510 mL
10 mM	0.3255 mL	1.6276 mL	3.2551 mL	16.2755 mL
20 mM	0.1628 mL	0.8138 mL	1.6276 mL	8.1378 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc