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Ononetin

Name: Ononetin
Brand: TargetMol
SKU: T23107
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23107Cas No. 487-49-0

Alias 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone

Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).

Ononetin

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Purity: 98.06%

Catalog No. T23107Alias 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenoneCas No. 487-49-0

Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).

Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$72	In Stock
25 mg	$139	In Stock
50 mg	$198	In Stock
100 mg	$297	In Stock
200 mg	$455	In Stock
500 mg	$736	In Stock

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Batch Information

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Purity:98.06%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).
Targets&IC50	TRPM3:0.3 μM
In vitro	Administration of 1-10 μM Ononetin completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones[1].
In vivo	Intraperitoneal injection of 10 mg/kg Ononetin completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms[2].
Synonyms	2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone

Chemical Properties

Molecular Weight	258.27
Formula	C₁₅H₁₄O₄
Cas No.	487-49-0
Smiles	COC1=CC=C(CC(=O)C2=C(O)C=C(O)C=C2)C=C1
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (212.96 mM), Sonication is recommended.

Ethanol: < 30 mg/mL (116.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8719 mL	19.3596 mL	38.7192 mL	193.5958 mL
5 mM	0.7744 mL	3.8719 mL	7.7438 mL	38.7192 mL
10 mM	0.3872 mL	1.9360 mL	3.8719 mL	19.3596 mL
20 mM	0.1936 mL	0.9680 mL	1.9360 mL	9.6798 mL
50 mM	0.0774 mL	0.3872 mL	0.7744 mL	3.8719 mL
100 mM	0.0387 mL	0.1936 mL	0.3872 mL	1.9360 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc