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Anti-Phospho-Bcl-xL (Thr115) Polyclonal Antibody 2
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Catalog No. TMAB-10383
Anti-Phospho-Bcl-xL (Thr115) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Bcl-xL (Thr115). Anti-Phospho-Bcl-xL (Thr115) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-Bcl-xL (Thr115) Polyclonal Antibody 2
Anti-Phospho-Bcl-xL (Thr115) Polyclonal Antibody 2
Copy Product Info😃Good
Catalog No. TMAB-10383
Anti-Phospho-Bcl-xL (Thr115) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Bcl-xL (Thr115). Anti-Phospho-Bcl-xL (Thr115) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-Bcl-xL (Thr115) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Bcl-xL (Thr115). Anti-Phospho-Bcl-xL (Thr115) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Horse,Sheep) |
| Verified Activity | 1. Independently Validated Antibody, image provided by Science Direct, badge number 029725:Formalin-fixed and paraffin embedded human prostate cancer labeled with Rabbit Anti-phospho-Bcl-xL (Thr115) Polyclonal Antibody, Unconjugated (TMAB-10383) at 1: 250 overnight at 4C followed by conjugation to the secondary antibody Envision Plus Horse Radish Peroxidase conjugated anti-rabbit antibody for two hours and DAB staining 2. Formalin-fixed and paraffin embedded human ovary labeled with Rabbit Anti-phospho-Bcl-xL (Thr115) Polyclonal Antibody, Unconjugated (TMAB-10383) at 1: 250 overnight at 4C followed by conjugation to the secondary antibody and DAB staining 3. Paraformaldehyde-fixed, paraffin embedded (mouse intestine tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (Bcl-xL (Thr115)) Polyclonal Antibody, Unconjugated (TMAB-10383) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 4. Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (phospho-Bcl-xL (Thr115)) Polyclonal Antibody, Unconjugated (TMAB-10383) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 5. Paraformaldehyde-fixed, paraffin embedded (mouset brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (phospho-Bcl-xL (Thr115)) Polyclonal Antibody, Unconjugated (TMAB-10383) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, centrosome. Note=Mitochondrial membranes and perinuclear envelope. Localizes to the centrosome when phosphorylated at Ser-49. |
| Tissue Specificity | Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | bs-1336P is one synthetic peptide derived from human Bcl-xL. The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human BCL2L1 around the phosphorylation site of Thr115 |
| Antigen Species | Human |
| Gene Name | BCL2L1 |
| Gene ID | |
| Protein Name | Bcl-2-like protein 1 |
| Uniprot ID | |
| Function | Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
Isoform Bcl-X(S) promotes apoptosis. |
| Molecular Weight | Theoretical: 26 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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