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Anti-Phosphor-PPP3CA (Ser469) Polyclonal Antibody
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Catalog No. TMAB-11244
Anti-Phosphor-PPP3CA (Ser469) Polyclonal Antibody is a Rabbit antibody targeting Phosphor-PPP3CA (Ser469). Anti-Phosphor-PPP3CA (Ser469) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phosphor-PPP3CA (Ser469) Polyclonal Antibody
Anti-Phosphor-PPP3CA (Ser469) Polyclonal Antibody
😃Good
Catalog No. TMAB-11244
Anti-Phosphor-PPP3CA (Ser469) Polyclonal Antibody is a Rabbit antibody targeting Phosphor-PPP3CA (Ser469). Anti-Phosphor-PPP3CA (Ser469) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phosphor-PPP3CA (Ser469) Polyclonal Antibody is a Rabbit antibody targeting Phosphor-PPP3CA (Ser469). Anti-Phosphor-PPP3CA (Ser469) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Chicken,Cow,Rabbit,GuineaPig) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. |
| Tissue Specificity | Interacts with CHP1 and CHP2. Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with CRTC2, MYOZ1, MYOZ2 and MYOZ3. Interacts with DNM1L; the interaction dephosphorylates DNM1L and regulates its translocation to mitochondria. Interacts with CMYA5; this interaction represses calcineurin activity in muscle. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Calcineurin, a major soluble calmodulin binding protein in the brain, a Ca2+/calmodulin dependent serine/threonine protein phosphatase, with a relatively narrow substrate specificity. This metalloenzyme, also known as phosphatase 2B, is a heterodimer composed of a calmodulin binding, catalytic alpha subunit 61 kDa, calcineurin A) and calcium binding beta subunit (18 kDa, calcineurin B). The Ca2+ binding subunit, calcineurin B, is immunologically conserved from yeast to mammals. The presence of 2 different calcineurin B isoforms (beta 1 and beta 2) has been reported in rat testis. The catalytic subunit of calcineurin, calcineurin A, isolated from different tissues or different organisms, exhibits some immunological heterogeneity. Further, there are at least 2 isoforms of calcineurin A in bovine brain (alpha 1 and alpha 2, 61 and 59 kDa, respectively). |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human PPP3CA around the phosphorylation site of Ser469 |
| Antigen Species | Human |
| Gene Name | PPP3CA |
| Gene ID | |
| Protein Name | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform |
| Uniprot ID | |
| Function | Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. |
| Molecular Weight | Theoretical: 57 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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