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4A7C-301-Nurr1 Agonist

Catalog No. T83894

Synonyms: 4A7C-301-Nuclear Receptor-Related 1

The compound 4A7C-301-Nurr1 agonist is a specific agonist for the nuclear receptor-related 1 (Nurr1). By binding to the Nurr1 ligand-binding domain with an IC50 value of 48.22 nM, it enhances the transcriptional activity of both Nurr1-LBD and the full-length Nurr1, as demonstrated in reporter assays using SK-N-BE(2)C human neuroblastoma cells, with EC50 values of 6.53 and 50-70 µM, respectively. Additionally, administration of 4A7C-301-Nurr1 agonist at a dosage of 5 mg/kg per day has been shown to mitigate dopaminergic cell death in the striatum and substantia nigra pars compacta and ameliorate motor and olfactory deficits in mouse models of Parkinson's disease, circumventing the induction of dyskinesia-like behaviors. These models were induced either by the neurotoxin MPTP or by overexpression of α-synuclein.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

4A7C-301-Nurr1 Agonist Chemical Structure

4A7C-301-Nurr1 Agonist, CAS N/A

Pack Size	Availability	Price/USD
500 μg	35 days	$ 65.00
1 mg	35 days	$ 98.00
5 mg	35 days	$ 418.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	4A7C-301-Nuclear Receptor-Related 1
Molecular Weight	524.10
Formula	C27H38ClN9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 20 mg/ml

Ethanol: 30 mg/ml

DMSO: 20 mg/ml

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

4A7C-301-Nurr1 Agonist 4A7C-301-Nuclear Receptor-Related 1 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.