Shopping Cart
Remove All
Your shopping cart is currently empty
TNF-α-IN-18
Copy Product Info
😃Good
Catalog No. T88696Cas No. 1272322-42-5
TNF-α-IN-18 (Compound 61) is a small molecule inhibitor of tumor necrosis factor-alpha (TNF-α) that operates with a IC50 of 1.8µM. TNF-α-IN-18 effectively blocks the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), thereby suppressing the downstream TNF signaling pathway; TNF-α-IN-18 exhibits minimal cytotoxicity in mouse fibroblast LM cells with a CC50 greater than 50 µM. TNF-α-IN-18has been shown to alleviate sepsis induced by TNF or lipopolysaccharide in mouse models, and provides significant protection against the development and progression of rheumatoid arthritis in murine models.
TNF-α-IN-18
Copy Product Info😃Good
Purity: 99.77%
Catalog No. T88696Cas No. 1272322-42-5
TNF-α-IN-18 (Compound 61) is a small molecule inhibitor of tumor necrosis factor-alpha (TNF-α) that operates with a IC50 of 1.8µM. TNF-α-IN-18 effectively blocks the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), thereby suppressing the downstream TNF signaling pathway; TNF-α-IN-18 exhibits minimal cytotoxicity in mouse fibroblast LM cells with a CC50 greater than 50 µM. TNF-α-IN-18has been shown to alleviate sepsis induced by TNF or lipopolysaccharide in mouse models, and provides significant protection against the development and progression of rheumatoid arthritis in murine models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $39 | - | In Stock | |
| 10 mg | $63 | - | In Stock | |
| 25 mg | $98 | - | In Stock | |
| 50 mg | $163 | - | In Stock | |
| 100 mg | $263 | - | In Stock | |
| 200 mg | $392 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.77%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TNF-α-IN-18 (Compound 61) is a small molecule inhibitor of tumor necrosis factor-alpha (TNF-α) that operates with a IC50 of 1.8µM. TNF-α-IN-18 effectively blocks the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), thereby suppressing the downstream TNF signaling pathway; TNF-α-IN-18 exhibits minimal cytotoxicity in mouse fibroblast LM cells with a CC50 greater than 50 µM. TNF-α-IN-18has been shown to alleviate sepsis induced by TNF or lipopolysaccharide in mouse models, and provides significant protection against the development and progression of rheumatoid arthritis in murine models. |
| Molecular Weight | 336.67 |
| Formula | C16H7ClF2O4 |
| Cas No. | 1272322-42-5 |
| Smiles | O=C(O)C=1C(=O)C2=CC=C(Cl)C=C2OC1C=3C=C(F)C=CC3F |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (237.62 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy TNF-α-IN-18 | purchase TNF-α-IN-18 | TNF-α-IN-18 cost | order TNF-α-IN-18 | TNF-α-IN-18 chemical structure | TNF-α-IN-18 formula | TNF-α-IN-18 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.