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Anti-Vitronectin Polyclonal Antibody

🥰Excellent
Catalog No. TMAB-14117

Antibody Type: Rabbit Polyclonal
Application: IHC-P,IHC-Fr,IF
Reactivity: Mouse (predicted:Human,Rat,Dog,Cow)

Anti-Vitronectin Polyclonal Antibody

Anti-Vitronectin Polyclonal Antibody

🥰Excellent
Catalog No. TMAB-14117
Antibody Type: Rabbit Polyclonal
Application: IHC-P,IHC-Fr,IF
Reactivity: Mouse (predicted:Human,Rat,Dog,Cow)
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Product Introduction

Bioactivity
Description
Anti-Vitronectin Polyclonal Antibody is a Rabbit antibody targeting Vitronectin. Anti-Vitronectin Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Dog,Cow)
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted, extracellular space.
Tissue SpecificityPlasma.
ConstructionHybridoma Polyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundVitronectin (also known as serum spreading factor, S protein of complement or epibolin) is one of the major multifunctional cell adhesive glycoproteins in mammalian plasma and serum. It is a monomeric acidic glycoprotein detected as a mixture of 75 kD and 65 kD polypeptides. Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b9 complex. Vitronectin promotes cell adhesion and spreading by binding through its cell attachment tripeptide Arg-Gly-Asp (RG-D), activity which is mediated by several different integrin receptors. Apart from the significance for identifying the molecule in the above situations, it also plays an important role in events such as embryonal development, deposition of vitronectin in a number of fibrotic disease states, carcinomas and metastases.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human Vitronectin
Antigen Species
Human
Gene Name
VTN
Gene ID
Protein Name
Vitronectin
Uniprot ID
Function
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity).
Chemical Properties
Molecular WeightTheoretical: 9/52 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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