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Bavituximab
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Catalog No. T77401Cas No. 648904-28-3
Alias Anti-PS MAb 3G4
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody targeting phosphatidylserine (PS) with vascular targeting and immunomodulatory properties, capable of reactivating anti-tumor immunity to inhibit tumor growth. It has anti-cancer activity and is frequently used with Paclitaxel and Carboplatin in non-small cell lung cancer studies.
Bavituximab
Bavituximab
😃Good
Catalog No. T77401Alias Anti-PS MAb 3G4Cas No. 648904-28-3
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody targeting phosphatidylserine (PS) with vascular targeting and immunomodulatory properties, capable of reactivating anti-tumor immunity to inhibit tumor growth. It has anti-cancer activity and is frequently used with Paclitaxel and Carboplatin in non-small cell lung cancer studies.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $413 | - | In Stock | |
| 5 mg | $987 | - | In Stock | |
| 10 mg | $1,650 | - | In Stock | |
| 25 mg | $2,460 | - | In Stock | |
| 50 mg | $3,320 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody targeting phosphatidylserine (PS) with vascular targeting and immunomodulatory properties, capable of reactivating anti-tumor immunity to inhibit tumor growth. It has anti-cancer activity and is frequently used with Paclitaxel and Carboplatin in non-small cell lung cancer studies. |
| In vitro | Bavituximab binds to exposed phosphatidylserine (PS) molecules through the serum protein β2-glycoprotein 1 (β2GP1)[1], inducing antibody-dependent cellular cytotoxicity and leading to the destruction of tumor vessels[1]. Bavituximab (10 μg/mL; 48 h) binds to PS induced by 10 μM Sorafenib in HUVEC and bEnd.3 cells[2]. |
| In vivo | Sorafenib induces anionic phospholipid exposure in a mouse tumor model, which is detected by Bavituximab (100 μg/mouse; i.v.; single dose) administered 48 hours post-Sorafenib treatment[2]. |
| Synonyms | Anti-PS MAb 3G4 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Phosphatidylserine |
| Molecular Weight | 145.3 kDa |
| Cas No. | 648904-28-3 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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