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Bavituximab

Catalog No. T77401 CAS 648904-28-3

Synonyms: Anti-PS MAb 3G4

Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody against phosphatidylserine (PS) with vascular targeting and immunomodulatory properties. It can reactivate anti-tumor immunity to inhibit tumor growth. Bavituximab has anti-cancer activity and is often used in combination with Paclitaxel and Carboplatin to study non-small cell lung cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Bavituximab

Bavituximab, CAS 648904-28-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 497.00
5 mg	In stock	$ 1,230.00
10 mg	In stock	$ 1,990.00
25 mg	In stock	$ 2,960.00
50 mg	In stock	$ 3,920.00
100 mg	In stock	$ 5,380.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a monoclonal antibody against phosphatidylserine (PS) with vascular targeting and immunomodulatory properties. It can reactivate anti-tumor immunity to inhibit tumor growth. Bavituximab has anti-cancer activity and is often used in combination with Paclitaxel and Carboplatin to study non-small cell lung cancer.
In vitro	Bavituximab binds to exposed phosphatidylserine (PS) molecules through the serum protein β2-glycoprotein 1 (β2GP1)[1]. Bavituximab induces antibody-dependent cellular cytotoxicity by binding to PS, leading to the destruction of tumor vessels[1]. Bavituximab (10 μg/mL; 48 h) binds to exposed phosphatidylserine (PS) induced by 10 μM Sorafenib in HUVEC and bEnd.3 cells[2].
In vivo	Sorafenib induces exposure of anionic phospholipids in a mouse tumor model. Bavituximab (100 μg/mouse; i.v.; single dose; administered 48 h after Sorafenib treatment) detects phosphatidylserine exposure in vivo[2].

Synonyms	Anti-PS MAb 3G4
Molecular Weight	N/A
CAS No.	648904-28-3

Storage

store at low temperature

store at -80°C

References and Literature

1. Digumarti R, et al. Bavituximab plus paclitaxel and carboplatin for the treatment of advanced non-small-cell lung cancer. Lung Cancer. 2014 Nov;86(2):231-6. 2. Cheng X, et al. Antibody-Mediated Blockade of Phosphatidylserine Enhances the Antitumor Effect of Sorafenib in Hepatocellular Carcinomas Xenografts. Ann Surg Oncol. 2016 Dec;23(Suppl 5):583-591.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bavituximab 648904-28-3 Others Anti-PS MAb 3G4 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.