Shopping Cart

Your shopping cart is currently empty

Fangchinoline

Name: Fangchinoline
Brand: TargetMol
SKU: T3122
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T3122Cas No. 436-77-1

Alias Tetrandrine B, Hanfangichin B, (+)-Limacine, (+)-Fangchinoline

Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.

Fangchinoline

Copy Product Info

🥰Excellent

Purity: 99.86%

Catalog No. T3122Alias Tetrandrine B, Hanfangichin B, (+)-Limacine, (+)-FangchinolineCas No. 436-77-1

Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$62	In Stock	In Stock
25 mg	$97	In Stock	In Stock
50 mg	$139	In Stock	In Stock
100 mg	$213	In Stock	In Stock
200 mg	$318	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Fangchinoline AI Summary

Fangchinoline exhibits diverse and significant bioactivities. It inhibits formyl-methionyl-leucyl-phenylalanine-induced superoxide generation in PMNC with an inhibition rate of 82.4%, indicating potential anti-inflammatory properties and regulation of oxidative stress and immune responses. It inhibits COX1 with an IC50 of 129,000.0 nM and shows cytotoxicity against various human cancer cell lines, including KB, MCF-7, and K562, with varying IC50 values. The compound also demonstrates strong antiplasmodial activity against both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum, with IC50 values of 179.0 nM and 306.0 nM, respectively. It exhibits antiamoebic activity against Entamoeba histolytica (IC50 = 14.71 ug/mL) and antibacterial activity against methicillin-resistant Staphylococcus aureus (MIC = 6.0 ug/mL). In addition, Fangchinoline induces rat C/EBPalpha expression in human U937 cells, increases Rhodamine 123 accumulation in HCT15 cells, and shows significant antiviral activity against SARS-CoV-2 in HEK293T cells with an IC50 of 193.0 nM. Despite its broad cytotoxic and inhibitory effects, it displays low cytotoxicity against certain cell lines and does not significantly inhibit AKT activity (IC50 > 20000.0 nM). Moreover, it has moderate selectivity indices in antiplasmodial assays, suggesting a balance between efficacy and cytotoxicity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.
Synonyms	Tetrandrine B, Hanfangichin B, (+)-Limacine, (+)-Fangchinoline

Chemical Properties

Molecular Weight	608.72
Formula	C₃₇H₄₀N₂O₆
Cas No.	436-77-1
Smiles	COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(O)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34
Relative Density.	1.204 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 49.5 mg/mL (81.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6428 mL	8.2140 mL	16.4279 mL	82.1396 mL
5 mM	0.3286 mL	1.6428 mL	3.2856 mL	16.4279 mL
10 mM	0.1643 mL	0.8214 mL	1.6428 mL	8.2140 mL
20 mM	0.0821 mL	0.4107 mL	0.8214 mL	4.1070 mL
50 mM	0.0329 mL	0.1643 mL	0.3286 mL	1.6428 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc