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Anti-PSGL-1/CD162 Antibody (5Q473) is a Mouse antibody targeting PSGL-1/CD162. Anti-PSGL-1/CD162 Antibody (5Q473) can be used in IHC-P.
Description | Anti-PSGL-1/CD162 Antibody (5Q473) is a Mouse antibody targeting PSGL-1/CD162. Anti-PSGL-1/CD162 Antibody (5Q473) can be used in IHC-P. |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 5Q473 |
Reactivity | Human |
Verified Activity | 1. Immunochemical staining of human SELPLG in human spleen with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human SELPLG in human tonsil with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. |
Application | IHC-P |
Recommended Dose | IHC-P: 1:30-1:100 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | P-selectin glycoprotein ligand-1 (PSGL-1), also known as SELPLG or CD162, is the high affinity ounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. PSGL-1 is a mucin-type glycoprotein, expressed on leukocytes and platelets as a homodimer of two disulfide-linked subunits of ~12 kD. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 protein requires two distinct posttranslational modifications for the Ca2+-dependent recognition by the lectin domain of P-selectin, that is tyrosine sulfation and specific O-linked glycosylation (sialic acid and fucose). PSGL-1 can also bind to other two members of the selectin family, E-selectin (endothelial) and L-selectin (leukocyte), but binds best to P-selectin. |
Conjucates | Unconjugated |
Immunogen | Recombinant Human PSGL-1/CD162/SELPLG Protein (TMPY-03531) |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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