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Sumanirole maleate

Name: Sumanirole maleate
Brand: TargetMol
SKU: TQ0140
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0140Cas No. 179386-44-8

Alias U-95666E, U95666E, PNU-95666, PNU95666

Sumanirole maleate (PNU-95666E) is a D2 receptor full agonist with high selectivity (ED50 = 46 nM) that improves motor function in patients with Parkinson's disease and plays an important role in the study of restless legs syndrome.

Sumanirole maleate

😃Good

Catalog No. TQ0140Alias U-95666E, U95666E, PNU-95666, PNU95666Cas No. 179386-44-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$69	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Sumanirole maleate (PNU-95666E) is a D2 receptor full agonist with high selectivity (ED50 = 46 nM) that improves motor function in patients with Parkinson's disease and plays an important role in the study of restless legs syndrome.
Targets&IC50	D2 receptor:46 nM (EC50)
Synonyms	U-95666E, U95666E, PNU-95666, PNU95666

Chemical Properties

Molecular Weight	319.31
Formula	C₁₅H₁₇N₃O₅
Cas No.	179386-44-8
Smiles	C(=C\C(O)=O)\C(O)=O.O=C1N2C3=C(C[C@@H](NC)C2)C=CC=C3N1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (125.27 mM), Sonication is recommended.

H2O: 8 mg/mL (25.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1318 mL	15.6588 mL	31.3175 mL	156.5876 mL
5 mM	0.6264 mL	3.1318 mL	6.2635 mL	31.3175 mL
10 mM	0.3132 mL	1.5659 mL	3.1318 mL	15.6588 mL
20 mM	0.1566 mL	0.7829 mL	1.5659 mL	7.8294 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0626 mL	0.3132 mL	0.6264 mL	3.1318 mL
100 mM	0.0313 mL	0.1566 mL	0.3132 mL	1.5659 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc