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JAK3-IN-9

Catalog No. T61814 CAS 1430095-30-9

JAK3-IN-9 is a potent and orally active inhibitor of the Janus kinase 3 (JAK3) enzyme, displaying an impressive IC50 value of 1.7 nM. It exhibits high selectivity towards the JAK3 signaling pathway, making it a valuable tool for studying autoimmune diseases. Additionally, JAK3-IN-9 possesses desirable characteristics such as low toxicity and excellent oral bioavailability. It also demonstrates promising anti-arthritis activity, thus enhancing its potential as a therapeutic agent [1].

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JAK3-IN-9, CAS 1430095-30-9

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JAK3-IN-9 is a potent and orally active inhibitor of the Janus kinase 3 (JAK3) enzyme, displaying an impressive IC50 value of 1.7 nM. It exhibits high selectivity towards the JAK3 signaling pathway, making it a valuable tool for studying autoimmune diseases. Additionally, JAK3-IN-9 possesses desirable characteristics such as low toxicity and excellent oral bioavailability. It also demonstrates promising anti-arthritis activity, thus enhancing its potential as a therapeutic agent [1].
In vitro	JAK3-IN-9 (compound 11i) exhibits a high level of selective inhibition towards JAK3, achieving an IC50 value of 1.7 nM [1]. In Cell Viability Assays using PBMCs at a concentration of 1 μM and an incubation time of 30 minutes, it demonstrated preferential inhibition of JAK3 [1].
In vivo	JAK3-IN-9, referred to as compound 11i, demonstrated selective inhibition of JAK3 cytokine signaling in primary cells when administered orally at dosages of 3, 10, and 30 mg/kg to female Lewis rats once daily for 20 days. Additionally, it exhibited a high area under the curve (AUC) of 2104 μg/ml, increased the half-life to 2.56 hours, and showed favorable oral bioavailability of 48% upon a single intravenous injection at 1 mg/kg in male DBA1j mice aged 8 to 12 weeks. Furthermore, JAK3-IN-9 significantly reduced paw swelling in a dose-dependent manner, with an effective dose (ED50) value of 10 mg/kg, after oral administration once daily for 20 days at a dose of 30 mg/kg. These results, obtained from studies conducted on male DBA1j mice and female Lewis rats, indicate its potential as an anti-arthritis agent in the CIA mice model.

Molecular Weight	393.46
Formula	C17H23N5O4S
CAS No.	1430095-30-9

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JAK3-IN-9 1430095-30-9 inhibitor inhibit

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