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PROTAC PTK6 ligand-1

Name: PROTAC PTK6 ligand-1
Brand: TargetMol
SKU: T77928
Rating: 4.5 (1 reviews)

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Catalog No. T77928Cas No. 2408341-98-8

PROTAC PTK6 ligand-1 is a functional intermediate used in the preparation of BTK kinase inhibitors and serves as a key synthetic building block for proteolysis-targeting chimera development, including the synthesis of ARD-61, PROTAC PTK6 ligand-1 enables targeted protein degradation studies and facilitating advanced medicinal chemistry research focused on kinase-driven disease models.

PROTAC PTK6 ligand-1

😃Good

Catalog No. T77928Cas No. 2408341-98-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	540.63
Formula	C₂₇H₃₂N₄O₆S
Cas No.	2408341-98-8
Smiles	C([C@H](C(C)C)C1=CC(C)=NO1)(=O)N2[C@H](C(N[C@@H](CC(O)=O)C3=CC=C(C=C3)C4=C(C)N=CS4)=O)C[C@@H](O)C2

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (147.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8497 mL	9.2485 mL	18.4969 mL	92.4847 mL
5 mM	0.3699 mL	1.8497 mL	3.6994 mL	18.4969 mL
10 mM	0.1850 mL	0.9248 mL	1.8497 mL	9.2485 mL
20 mM	0.0925 mL	0.4624 mL	0.9248 mL	4.6242 mL
50 mM	0.0370 mL	0.1850 mL	0.3699 mL	1.8497 mL
100 mM	0.0185 mL	0.0925 mL	0.1850 mL	0.9248 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc