Select your Country or Region

  • TargetMol | Compound LibraryArgentinaArgentina
  • TargetMol | Compound LibraryAustraliaAustralia
  • TargetMol | Compound LibraryAustriaAustria
  • TargetMol | Compound LibraryBelgiumBelgium
  • TargetMol | Compound LibraryBrazilBrazil
  • TargetMol | Compound LibraryBulgariaBulgaria
  • TargetMol | Compound LibraryCroatiaCroatia
  • TargetMol | Compound LibraryCyprusCyprus
  • TargetMol | Compound LibraryCzechCzech
  • TargetMol | Compound LibraryDenmarkDenmark
  • TargetMol | Compound LibraryEgyptEgypt
  • TargetMol | Compound LibraryEstoniaEstonia
  • TargetMol | Compound LibraryFinlandFinland
  • TargetMol | Compound LibraryFranceFrance
  • TargetMol | Compound LibraryGermanyGermany
  • TargetMol | Compound LibraryGreeceGreece
  • TargetMol | Compound LibraryHong KongHong Kong
  • TargetMol | Compound LibraryHungaryHungary
  • TargetMol | Compound LibraryIcelandIceland
  • TargetMol | Compound LibraryIndiaIndia
  • TargetMol | Compound LibraryIrelandIreland
  • TargetMol | Compound LibraryIsraelIsrael
  • TargetMol | Compound LibraryItalyItaly
  • TargetMol | Compound LibraryJapanJapan
  • TargetMol | Compound LibraryKoreaKorea
  • TargetMol | Compound LibraryLatviaLatvia
  • TargetMol | Compound LibraryLebanonLebanon
  • TargetMol | Compound LibraryMalaysiaMalaysia
  • TargetMol | Compound LibraryMaltaMalta
  • TargetMol | Compound LibraryMoroccoMorocco
  • TargetMol | Compound LibraryNetherlandsNetherlands
  • TargetMol | Compound LibraryNew ZealandNew Zealand
  • TargetMol | Compound LibraryNorwayNorway
  • TargetMol | Compound LibraryPolandPoland
  • TargetMol | Compound LibraryPortugalPortugal
  • TargetMol | Compound LibraryRomaniaRomania
  • TargetMol | Compound LibrarySingaporeSingapore
  • TargetMol | Compound LibrarySlovakiaSlovakia
  • TargetMol | Compound LibrarySloveniaSlovenia
  • TargetMol | Compound LibrarySpainSpain
  • TargetMol | Compound LibrarySwedenSweden
  • TargetMol | Compound LibrarySwitzerlandSwitzerland
  • TargetMol | Compound LibraryTaiwan,ChinaTaiwan,China
  • TargetMol | Compound LibraryThailandThailand
  • TargetMol | Compound LibraryTurkeyTurkey
  • TargetMol | Compound LibraryUnited KingdomUnited Kingdom
  • TargetMol | Compound LibraryUnited StatesUnited States
  • TargetMol | Compound LibraryOther CountriesOther Countries
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.

  • Beta-Tocopherol
    TN1441148-03-8
    Beta-Tocopherol shows effect on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA).
    • $54
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
  • Notoginsenoside R1
    T296180418-24-2
    Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
    • $63
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
  • SCH772984
    T6066942183-80-4
    SCH 772984 is a potent inhibitor of ERK1 ERK2 (IC50: 4 1 nM) and has only weak inhibitory for other 300 tested kinases.
    • $48
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
  • CK2/ERK8-IN-1
    T108271085822-09-8In house
    CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM).
    • $30
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Allicin
    T3123539-86-6
    Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth muscle cells' proliferation and migration induced by insulin, which may be related to the inhibition of the activation of ERK signal path. Allicin is beneficial in reducing blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats, it may beneficially affect two risk factors for atherosclerosis-hyperlipidemia and hypertension.
    • $40
    In Stock
    Size
    QTY
  • Farrerol
    T6S052524211-30-1
    1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection and could be useful in protection against bovine mastitis. 3. Farrerol inactivates KEAP-1 or act
    • $110
    In Stock
    Size
    QTY
  • Astragaloside IV
    T297384687-43-4
    Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
    • $32
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • magnolin
    T385731008-18-1
    Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.
    • $93
    In Stock
    Size
    QTY
  • Nothofagin
    TN199611023-94-2In house
    Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases.
    • $489
    In Stock
    Size
    QTY
  • A-674563 2HCl(552325-73-2(fb-2hcl))
    T6139L
    A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
    • $78
    In Stock
    Size
    QTY
  • CHPG hydrochloride
    T10809L In house
    CHPG hydrochloride is a selective agonist of mGluR5.
    • $85
    In Stock
    Size
    QTY
  • Astragaloside
    T408217429-69-5
    Astragaloside, one of the main active ingredients in Astragalus membranaceus.
    • $50
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • ERK5-IN-6
    T777312734916-64-2
    ERK5-IN-6 is a potent inhibitor of ERK5 kinase.ERK5-IN-6 exhibits antiproliferative activity, anticonvulsant activity, and antitumor activity, and can be used in the study of central nervous system-related disorders.
    • $195
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • A-674563 HCl (552325-73-2(free base))
    T44442070009-66-2
    A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for Akt1 versus additional kinases in th
    • $77
    In Stock
    Size
    QTY
  • Prosaptide TX14(A) acetate
    TP1970L
    Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.
    • $148
    In Stock
    Size
    QTY
  • ZINC12409120
    T611221010888-06-8In house
    ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23:α-Klotho interaction.
    • $350
    In Stock
    Size
    QTY
  • Gardenin A
    TN411421187-73-5
    Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
    • $197
    In Stock
    Size
    QTY
  • AY 77
    T411901835734-92-3In house
    AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM). AY 77 can promote migration of human breast cancer cells in vitro.
    • $686
    In Stock
    Size
    QTY
  • Epieriocalyxin A
    TN3967191545-24-1
    Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
    • $216
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • EF24
    T27242342808-40-6In house
    EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral squamous cell carcinoma (OSCC) via deactivation of the MAPK/ERK signaling pathway.
    • $33
    In Stock
    Size
    QTY
  • PAF (C16)
    T2154774389-68-7In house
    PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.
    • $67
    In Stock
    Size
    QTY
  • ROCK-IN-5
    T67748692870-25-0In house
    ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC. ROCK-IN-5 exhibits the potential for cardiac, proliferative and neurodegenerative diseases research.
    • $38
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
  • Olomoucine
    T21588101622-51-9In house
    Olomoucine is an ATP competitive inhibitor of Cdk2/cyclin A, Cdc2/CyclinB, CDK2/CyclinE, CDK5/p35, and ERK1/p44 MAP kinase with IC50s of 7, 7, 7, 3 and 25 µM, respectively. Olomoucine regulates cell cycle and exhibits anti-melanin tumor activities.
    • $67
    In Stock
    Size
    QTY
  • ERK1/2 inhibitor 1
    T112262095719-90-5In house
    ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
    • $213
    In Stock
    Size
    QTY
  • Asperulosidic acid
    TN141025368-11-0
    Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.
    • $156
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • BIX02189
    T24161094614-85-3
    BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
    • $34
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Galangin
    T3668548-83-4
    Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Temuterkib
    T40911951483-29-6
    Temuterkib (LY3214996) is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity.
    • $64
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Rineterkib
    T112241715025-32-3
    Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
    • $96
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Tauroursodeoxycholate sodium
    T699335807-85-3
    Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
    • $30
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Lidocaine hydrochloride
    T114473-78-9
    Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
    • $45
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Honokiol
    T300135354-74-6
    Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
    • $50
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Licochalcone D
    T4518144506-15-0
    Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotective potential against myocardial is
    • $97
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Ulixertinib
    T7005869886-67-9
    Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.
    • $34
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • FR 180204
    T1956865362-74-9
    FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.
    • $36
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • 5α-Hydroxycostic acid
    TN3139132185-83-2
    5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
    • $162
    Backorder
    Size
    QTY
    TargetMol | Inhibitor Sale
    TargetMol | Citations Cited
  • Piperlongumine
    T694720069-09-4
    Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
    • $30
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Selumetinib
    T6218606143-52-6
    Selumetinib (AZD6244) (AZD6244) is an effective, specific inhibitor of MEK1 and ERK1/2 phosphorylation (IC50: 14/10 nM).
    • $47
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • AZD8330
    T6083869357-68-6
    AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
    • $48
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Bongkrekic acid
    T3606711076-19-0
    Bongkrekic acid (Bongkrekic Acid (ammonium salt)) is a mitochondrial toxin secreted by Burkholderia gladioli that inhibits adenine nucleotide translocase (ANT).Bongkrekic acid Bongkrekic acid Bongkrekic acid induces extracellular traps in neutrophils through signaling mediated by p38, ERK, PAD4, and P2X1.
    • Inquiry Price
    Size
    QTY
    TargetMol | Inhibitor Sale
    TargetMol | Citations Cited
  • Ravoxertinib
    T65111453848-26-4
    Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).
    • $34
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • PD98059
    T2623167869-21-8
    PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy.
    • $34
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Bohemine
    T2029189232-42-6
    Bohemine is a cyclin-dependent kinase inhibitor.
    • $47
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Sale
    TargetMol | Citations Cited
  • Atractylenolide II
    T5S016873069-14-4
    1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK and Akt inactivation, p53 dependent.
    • $140
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • ERK-IN-2
    T112252743576-56-7
    ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].
    • $1,520
    Backorder
    Size
    QTY
    TargetMol | Citations Cited
  • Cornuside
    T4S2326131189-57-6
    1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
    • $97
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Ro-3306
    T2356872573-93-8
    RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.
    • $32
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Tauroursodeoxycholate
    T253214605-22-2
    Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans.Tauroursodeoxycholate is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.
    • $50
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • Chrysoeriol
    TN1490491-71-4
    Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilator effect.
    • $88
    In Stock
    Size
    QTY
    TargetMol | Citations Cited
  • TBHQ
    T53641948-33-0
    TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.
    • $41
    In Stock
    Size
    QTY
    TargetMol | Citations Cited