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VPC-80051 racemate

Name: VPC-80051 racemate
Brand: TargetMol
SKU: T9005
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9005Cas No. 877969-69-2

VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach.

VPC-80051 racemate

🥰Excellent

Purity: 97.36%

Catalog No. T9005Cas No. 877969-69-2

VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach.

Pack Size	Price	Availability
1 mg	$58	In Stock
5 mg	$139	In Stock
10 mg	$222	In Stock
25 mg	$446	In Stock
50 mg	$689	In Stock
1 mL x 10 mM (in DMSO)	$153	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:97.36%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach.
In vitro	VPC-80051 directly interacts with hnRNP A1 RBD, reducing AR-V7 messenger levels in the 22Rv1 CRPC cell line.

Chemical Properties

Molecular Weight	301.29
Formula	C₁₆H₁₃F₂N₃O
Cas No.	877969-69-2
Smiles	CC(NC(=O)c1n[nH]c2ccccc12)c1ccc(F)c(F)c1
Relative Density.	1.358 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (182.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3191 mL	16.5953 mL	33.1906 mL	165.9531 mL
5 mM	0.6638 mL	3.3191 mL	6.6381 mL	33.1906 mL
10 mM	0.3319 mL	1.6595 mL	3.3191 mL	16.5953 mL
20 mM	0.1660 mL	0.8298 mL	1.6595 mL	8.2977 mL
50 mM	0.0664 mL	0.3319 mL	0.6638 mL	3.3191 mL
100 mM	0.0332 mL	0.1660 mL	0.3319 mL	1.6595 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc