Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tubulin Inhibitor 36 (Compound 10) serves as a potent novel inhibitor of tubulin polymerization, which consequently induces apoptosis in glioblastoma cells, reflected by an IC50 value of 1.5±0.1 μM. Exhibiting significant anti-mitotic activity, this compound demonstrates anti-tumor potential, particularly useful in glioblastoma multiforme (GBM) research [1].
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Description | Tubulin Inhibitor 36 (Compound 10) serves as a potent novel inhibitor of tubulin polymerization, which consequently induces apoptosis in glioblastoma cells, reflected by an IC50 value of 1.5±0.1 μM. Exhibiting significant anti-mitotic activity, this compound demonstrates anti-tumor potential, particularly useful in glioblastoma multiforme (GBM) research [1]. |
In vitro | Tubulin inhibitor 36 (Compound 10) exhibits antiproliferative activity against human tumor cell lines, demonstrating IC50 values of 0.039, 0.038, 0.022, 0.025, 0.037, 0.040, and 0.059 μM for HeLa, MCF7, U87 MG, T98G, HepG2, HCT8, and HT-29 cells, respectively [1]. Additionally, at a concentration of 100 nM over 24, 48, and 72 hours, Tubulin inhibitor 36 (Compound 10) can arrest mitosis and induce apoptosis in HeLa, MCF7, and U87 MG cells [1]. |
Molecular Weight | 356.83 |
Formula | C16H13ClN6S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Tubulin inhibitor 36 inhibitor inhibit