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Praeruptorin B

Name: Praeruptorin B
Brand: TargetMol
SKU: T4S1421
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4S1421Cas No. 73069-28-0

Alias Praeruptorin D, 81740-07-0

Praeruptorin B (Praeruptorin D), a compound found in the roots of Peuced, is an inhibitor of sterol regulatory element-binding proteins (SREBPs) that attenuates the metastatic ability of human renal cancer cells by targeting CTSC and CTSV expression, and can be used in the study of osteoporosis.

Praeruptorin B

🥰Excellent

Purity: 99.96%

Catalog No. T4S1421Alias Praeruptorin D, 81740-07-0Cas No. 73069-28-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$228	In Stock	In Stock
50 mg	$347	In Stock	In Stock
100 mg	$519	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.96%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Praeruptorin B (Praeruptorin D), a compound found in the roots of Peuced, is an inhibitor of sterol regulatory element-binding proteins (SREBPs) that attenuates the metastatic ability of human renal cancer cells by targeting CTSC and CTSV expression, and can be used in the study of osteoporosis.
In vitro	Praeruptorin B inhibited the activity of SREBPs and reduced intracellular lipid levels, and significantly down-regulated the expression of SREBP-1c and SREBP-2.Praeruptorin B potently reduced SRE-luciferase activity and the effect was dose-dependent.[1]
In vivo	Mice treated with 50 mg/kg Praeruptorin B weighed significantly less than those treated with the vector, although they were still heavier than mice fed regular chow, suggesting that Praeruptorin B ameliorates diet-induced obesity (DIO). Staining results showed that Praeruptorin B-treated mice exhibited less lipid accumulation than vector-treated mice. Elevated fasting blood glucose and insulin levels in high-fat diet-fed mice were significantly reduced by Praeruptorin B. The results showed that the elevated fasting blood glucose and insulin levels in Praeruptorin B-treated mice were significantly reduced. [1]
Synonyms	Praeruptorin D, 81740-07-0

Chemical Properties

Molecular Weight	426.46
Formula	C₂₄H₂₆O₇
Cas No.	73069-28-0
Smiles	O(C(/C(=C\C)/C)=O)[C@H]1C=2C3=C(C=CC2OC(C)(C)[C@H]1OC(/C(=C\C)/C)=O)C=CC(=O)O3
Relative Density.	1.24g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (46.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (4.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3449 mL	11.7244 mL	23.4489 mL	117.2443 mL
5 mM	0.4690 mL	2.3449 mL	4.6898 mL	23.4489 mL
10 mM	0.2345 mL	1.1724 mL	2.3449 mL	11.7244 mL
20 mM	0.1172 mL	0.5862 mL	1.1724 mL	5.8622 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc