BCMA/TNFRSF17 Protein, Human, Recombinant (mFc)

Name: BCMA/TNFRSF17 Protein, Human, Recombinant (mFc)
Brand: TargetMol
SKU: TMPY-05197
Price: 92 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: tumor necrosis factor receptor superfamily member 17, TNFRSF13A, CD269, BCMA, BCM) Copy Product Info

Synonyms: tumor necrosis factor receptor superfamily member 17, TNFRSF13A, CD269, BCMA, BCM

Catalog No. TMPY-05197 Copy Product Info

BCMA/TNFRSF17 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 32.3 kDa and the accession number is Q02223-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$92	-	In Stock
10 µg	$148	-	In Stock
20 µg	$246	-	In Stock
50 µg	$486	-	In Stock
100 µg	$820	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

Appearance:Lyophilized powder

Color:White

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COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	BCMA/TNFRSF17 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 32.3 kDa and the accession number is Q02223-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-mFc
Accession Number	Q02223-1
Construction	A DNA sequence encoding the human TNFRSF17 (NP_001183.2 ) (Met1-Ala54) was expressed with the Fc region of mouse IgG2a at the C-terminus. Predicted N terminal: Met 1
Protein Purity	≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	tumor necrosis factor receptor superfamily member 17, TNFRSF13A, CD269, BCMA, BCM
Research Background	Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

Chemical Properties

Molecular Weight

32.3 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.