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STING agonist-3

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Catalog No. T13014Cas No. 2138299-29-1

STING agonist-3 is a selective and non-nucleotide small-molecule STING agonist(pEC50 and pIC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer.

STING agonist-3
Other Forms of STING agonist-3:
STING agonist-3 trihydrochlorideT13014L
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STING agonist-3

😃Good
Catalog No. T13014Cas No. 2138299-29-1
STING agonist-3 is a selective and non-nucleotide small-molecule STING agonist(pEC50 and pIC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
Pack SizePriceAvailabilityQuantity
500 μg$22335 days
1 mg$41735 days
5 mg$1,72035 days
10 mg$2,87035 days
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Product Introduction

Bioactivity
Description
STING agonist-3 is a selective and non-nucleotide small-molecule STING agonist(pEC50 and pIC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
In vitro
STING agonist-3 exhibits activation of STING in cells(pEC50 of 7.5), this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter.In FRET assay, STING agonist-3 exhibits a pIC50 value of 9.5 . This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING.
Chemical Properties
Molecular Weight750.81
FormulaC37H42N12O6
Cas No.2138299-29-1
Relative Density.1.47 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 125 mg/mL (166.49 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3319 mL6.6595 mL13.3189 mL66.5947 mL
5 mM0.2664 mL1.3319 mL2.6638 mL13.3189 mL
10 mM0.1332 mL0.6659 mL1.3319 mL6.6595 mL
20 mM0.0666 mL0.3330 mL0.6659 mL3.3297 mL
50 mM0.0266 mL0.1332 mL0.2664 mL1.3319 mL
100 mM0.0133 mL0.0666 mL0.1332 mL0.6659 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

STING agonist-3STING agonist3STING agonist 3
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