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Ceftazidime Pentahydrate

Name: Ceftazidime Pentahydrate
Brand: TargetMol
SKU: T8261
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8261Cas No. 78439-06-2

Ceftazidime Pentahydrate is a cephalosporin antibiotic with activity against gram-negative bacilli, including Pseudomonas aeruginosa, and is used in the study of infectious diseases.

Ceftazidime Pentahydrate

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Purity: 99.39%

Catalog No. T8261Cas No. 78439-06-2

Ceftazidime Pentahydrate is a cephalosporin antibiotic with activity against gram-negative bacilli, including Pseudomonas aeruginosa, and is used in the study of infectious diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$29	In Stock	In Stock
500 mg	$42	In Stock	-
1 g	$72	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.39%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Ceftazidime Pentahydrate is a cephalosporin antibiotic with activity against gram-negative bacilli, including Pseudomonas aeruginosa, and is used in the study of infectious diseases.
In vitro	In Pseudomonas aeruginosa strains (PAO1, PA1, PA2), Ceftazidime pentahydrate (approximately 0-8 µg/mL; 24 h) demonstrated antibacterial and anti-biofilm activities, with minimum inhibitory concentration (MIC) values of 2-4 µg/mL[2].
In vivo	In the murine thigh infection model, Ceftazidime Pentahydrate (2000 mg; administered via a 2-hour intravenous infusion every 8 hours for a total of 24 hours) was able to reduce the bacterial density against the isogenic NDM (New Delhi metallo-β-lactamase) strain[4].

Chemical Properties

Molecular Weight	636.65
Formula	C₂₂H₂₂N₆O₇S₂.5H₂O
Cas No.	78439-06-2
Smiles	[O-]C(C1=C(C[N+]2=CC=CC=C2)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\OC(C)(C)C(O)=O)=O)([H])N1C3=O)=O.O.O.O.O.O
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (125.66 mM), Sonication is recommended.

H2O: 20 mg/mL (31.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (5.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5707 mL	7.8536 mL	15.7072 mL	78.5361 mL
5 mM	0.3141 mL	1.5707 mL	3.1414 mL	15.7072 mL
10 mM	0.1571 mL	0.7854 mL	1.5707 mL	7.8536 mL
20 mM	0.0785 mL	0.3927 mL	0.7854 mL	3.9268 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0314 mL	0.1571 mL	0.3141 mL	1.5707 mL
100 mM	0.0157 mL	0.0785 mL	0.1571 mL	0.7854 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc