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Ceftazidime Pentahydrate

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Catalog No. T8261Cas No. 78439-06-2

Ceftazidime Pentahydrate is a cephalosporin antibiotic with activity against gram-negative bacilli, including Pseudomonas aeruginosa, and is used in the study of infectious diseases.

Ceftazidime Pentahydrate
Other Forms of Ceftazidime Pentahydrate:

Ceftazidime Pentahydrate

🥰Excellent
Purity: 99.39%
Catalog No. T8261Cas No. 78439-06-2
Ceftazidime Pentahydrate is a cephalosporin antibiotic with activity against gram-negative bacilli, including Pseudomonas aeruginosa, and is used in the study of infectious diseases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
200 mg$29In StockIn Stock
500 mg$42In StockIn Stock
1 g$72In Stock-
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.39%
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Product Introduction

Bioactivity
Description
Ceftazidime Pentahydrate is a cephalosporin antibiotic with activity against gram-negative bacilli, including Pseudomonas aeruginosa, and is used in the study of infectious diseases.
In vitro
In Pseudomonas aeruginosa strains (PAO1, PA1, PA2), Ceftazidime pentahydrate (approximately 0-8 µg/mL; 24 h) demonstrated antibacterial and anti-biofilm activities, with minimum inhibitory concentration (MIC) values of 2-4 µg/mL[2].
In vivo
In the murine thigh infection model, Ceftazidime Pentahydrate (2000 mg; administered via a 2-hour intravenous infusion every 8 hours for a total of 24 hours) was able to reduce the bacterial density against the isogenic NDM (New Delhi metallo-β-lactamase) strain[4].
Chemical Properties
Molecular Weight636.65
FormulaC22H32N6O12S2
Cas No.78439-06-2
SmilesCC1=CN2[C@H](SC1)[C@H](NC(=O)C(=N\OC(C)(C)C(O)=O)\c1csc(N)n1)C2=O
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (125.66 mM), Sonication is recommended.
H2O: 20 mg/mL (31.41 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 3.3 mg/mL (5.18 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.5707 mL7.8536 mL15.7072 mL78.5361 mL
5 mM0.3141 mL1.5707 mL3.1414 mL15.7072 mL
10 mM0.1571 mL0.7854 mL1.5707 mL7.8536 mL
20 mM0.0785 mL0.3927 mL0.7854 mL3.9268 mL
DMSO
1mg5mg10mg50mg
50 mM0.0314 mL0.1571 mL0.3141 mL1.5707 mL
100 mM0.0157 mL0.0785 mL0.1571 mL0.7854 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

β-Lactamasethigh infectionlactamaseInhibitorinhibitinfectionGramGR-20263GR20263GR 20263Ceftazidime PentahydrateCeftazidimeBiofilmBacterialAntibiotic
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