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Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine

Name: Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine
Brand: TargetMol
SKU: T77598
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77598Cas No. 906258-69-3

Alias (4-(4-methoxyphenyl)piperazin-1-yl)(2-(4-methylpiperidin-1-yl)benzo[d]thiazol-6-yl)methanone

Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine ((4-(4-methoxyphenyl)piperazin-1-yl)(2-(4-methylpiperidin-1-yl)benzo[d]thiazol-6-yl)methanone) is a raw material for biosynthesis and can be used to synthesize various compounds.

Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine

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Purity: 98.9%

Catalog No. T77598Alias (4-(4-methoxyphenyl)piperazin-1-yl)(2-(4-methylpiperidin-1-yl)benzo[d]thiazol-6-yl)methanoneCas No. 906258-69-3

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	-	In Stock
5 mg	$52	-	In Stock
10 mg	$83	-	In Stock
25 mg	$180	-	In Stock
50 mg	$292	-	In Stock
100 mg	$405	-	In Stock
200 mg	$548	-	In Stock
1 mL x 10 mM (in DMSO)	$57	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.9%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine AI Summary

Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine exhibits multifaceted bioactivities, functioning prominently as an inhibitor and modulator across various biochemical pathways. It acts as a modulator of miRNAs and an activator/inhibitor of miR-21 with a potency of 8260.4 nM and inhibits Tau fibril formation with a Thioflavin T binding potency of 15848.9 nM. Additionally, it effectively inhibits the Nrf2 pathway with a potency of 4610.9 nM, Histone Lysine Methyltransferase G9a at 3548.1 nM, and BAZ2B at 22387.2 nM. The compound also suppresses Polymerase Iota at 89125.1 nM, Lassa Virus binding/entry at 1584.9 nM, and ATXN expression at 39810.7 nM while activating BRCA1 expression with a potency of 1584.9 nM. It inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 29092.9 nM (absence of CPT) and 23109.3 nM (presence of CPT) and shows inhibitory activity against PTHR with a potency of 125892.5 nM. Moreover, Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine is a potent inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 2840.0 nM and achieving 89.8% inhibition at 33.33 µM relative to the control. Surface plasmon resonance (SPR) analysis reveals a binding affinity (Kd) to MAGL of 710.0 nM. Additionally, it shows inhibitory/activator effects on firefly luciferase with a potency of 19011.5 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine ((4-(4-methoxyphenyl)piperazin-1-yl)(2-(4-methylpiperidin-1-yl)benzo[d]thiazol-6-yl)methanone) is a raw material for biosynthesis and can be used to synthesize various compounds.
Synonyms	(4-(4-methoxyphenyl)piperazin-1-yl)(2-(4-methylpiperidin-1-yl)benzo[d]thiazol-6-yl)methanone

Chemical Properties

Molecular Weight	450.6
Formula	C₂₅H₃₀N₄O₂S
Cas No.	906258-69-3
Smiles	C(=O)(C=1C=C2C(N=C(S2)N3CCC(C)CC3)=CC1)N4CCN(CC4)C5=CC=C(OC)C=C5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (33.29 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2193 mL	11.0963 mL	22.1926 mL	110.9632 mL
5 mM	0.4439 mL	2.2193 mL	4.4385 mL	22.1926 mL
10 mM	0.2219 mL	1.1096 mL	2.2193 mL	11.0963 mL
20 mM	0.1110 mL	0.5548 mL	1.1096 mL	5.5482 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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