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4'-Hydroxychalcone

Name: 4'-Hydroxychalcone
Brand: TargetMol
SKU: T7917
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7917Cas No. 2657-25-2

Alias 2-Benzal-4-Hydroxyacetophenone

4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity

4'-Hydroxychalcone

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Purity: 99.87%

Catalog No. T7917Alias 2-Benzal-4-HydroxyacetophenoneCas No. 2657-25-2

4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$40	-	In Stock
10 g	$56	-	In Stock
25 g	$92	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

4'-Hydroxychalcone AI Summary

4'-Hydroxychalcone exhibits a broad range of bioactivities across different biological systems and targets. It acts as a growth inhibitor of chloroquine-resistant Plasmodium falciparum K1 with an IC50 of 29600.0 nM and shows substantial inhibitory effects on Interleukin-1-beta production in human monocytes (IC50 = 6130.0 nM) and Leishmania donovani in vitro (IC50 = 16000.0 nM). Additionally, 4'-Hydroxychalcone inhibits the enzyme activities of hamster liver aldehyde dehydrogenase ALDH-2 (IC50 = 7000.0 nM) and mitochondrial monoamine oxidase MAO (IC50 = 4500.0 nM). In cellular assays, it demonstrates anti-proliferative properties with varying IC50 values against murine P388 cells, L1210 leukemia cells, human Molt 4/C8 T-lymphocyte cells, and Human CEM T-lymphocytes cells. It also induces NAD(P)H quinone reductase activity in Hepa 1c1c7 murine hepatoma cells (16.0 μM concentration). 4'-Hydroxychalcone exhibits inhibitory action against recombinant rat androgen receptors (IC50 = 57543.99 nM) and human tyrosyl-DNA phosphodiesterase 1 (TDP1). Furthermore, 4'-Hydroxychalcone shows a high affinity for enzymes involved in inflammatory pathways, such as cyclooxygenase and 5-lipoxygenase, and demonstrates inhibition of lipid peroxidation in rat liver microsomes. It has significant bioactivity as a larvicide against Culex quinquefasciatus, with an LC50 of 238.0 μmol/dm³, and exhibits pronounced antifungal activity against fluconazole-resistant Candida albicans. Moreover, 4'-Hydroxychalcone shows significant inhibitory activity against human MAOB (IC50 = 182.0 nM), with high selectivity over MAOA, and demonstrates antioxidant properties such as DPPH and ABTS radical scavenging activities. It also inhibits specific chaperone proteins in E. coli and human mitochondrial cells while affecting the ATPase activity of Escherichia coli GroEL. Lastly, the compound shows potential as a candidate for further studies due to its potency in various assays related to anti-coagulant, anti-inflammatory, antioxidant, and cytotoxic properties in different biological systems..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity
Synonyms	2-Benzal-4-Hydroxyacetophenone

Chemical Properties

Molecular Weight	224.25
Formula	C₁₅H₁₂O₂
Cas No.	2657-25-2
Smiles	OC1=CC=C(C=C1)C(=O)\C=C\C1=CC=CC=C1
Relative Density.	1.191 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (222.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4593 mL	22.2965 mL	44.5931 mL	222.9654 mL
5 mM	0.8919 mL	4.4593 mL	8.9186 mL	44.5931 mL
10 mM	0.4459 mL	2.2297 mL	4.4593 mL	22.2965 mL
20 mM	0.2230 mL	1.1148 mL	2.2297 mL	11.1483 mL
50 mM	0.0892 mL	0.4459 mL	0.8919 mL	4.4593 mL
100 mM	0.0446 mL	0.2230 mL	0.4459 mL	2.2297 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc