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Anti-CIB2 Antibody (3T556)
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Catalog No. TMAY-02393
Alias USH1J, KIP2, DFNB48, calcium and integrin binding family member 2
Anti-CIB2 Antibody (3T556) is a Rabbit antibody targeting CIB2. Anti-CIB2 Antibody (3T556) can be used in ELISA,ELISA(Det),IHC-P.
Anti-CIB2 Antibody (3T556)
Anti-CIB2 Antibody (3T556)
😃Good
Catalog No. TMAY-02393Alias USH1J, KIP2, DFNB48, calcium and integrin binding family member 2
Anti-CIB2 Antibody (3T556) is a Rabbit antibody targeting CIB2. Anti-CIB2 Antibody (3T556) can be used in ELISA,ELISA(Det),IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $94 | 7-10 days | |
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA, ELISA(Det), IHC-P Reactivity: Human |
| Alias | USH1J, KIP2, DFNB48, calcium and integrin binding family member 2 |
| Ig Type | Rabbit IgG |
| Clone | 3T556 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human CIB2 in human heart with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human CIB2 in human brain with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections). |
| Application | ELISA,ELISA(Det),IHC-P |
| Recommended Dose | ELISA: 1:5000-1:10000; IHC-P: 1:1000-1:4000; ELISA(Det): 1:1000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CIB2 (rh CIB2; TMPY-02289; O75838; Met 1-Ile 187). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is genetically heterogeneous. The mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J (USH1J). Furthermore, in zebrafish and Drosophila melanogaster, CIB2 is essential for the function and proper development of hair cells and retinal photoreceptor cells. We also show that CIB2 is a new member of the vertebrate Usher interactome. Variants in CIB2 can underlie either Usher syndrome type I (USH1J) or nonsyndromic hearing impairment (NSHI) (DFNB48). CIB2 is widely expressed in various human and animal tissues, mainly in skeletal muscle, nervous tissue, inner ear, and retina. The CIB2 protein is responsible for maintaining Ca(2+) homeostasis in cells and interacting with integrins-transmembrane receptors essential for cell adhesion, migration, and activation of signaling pathways. Calcium signaling pathway is crucial for signal transduction in the inner ear, and integrins regulate hair cell differentiation and maturation of the stereocilia. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CIB2 protein (TMPY-02289) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
Sci Citations
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