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Halopemide

Name: Halopemide
Brand: TargetMol
SKU: T15461
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15461Cas No. 59831-65-1

Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2). Halopemid is an antagonist of dopamine receptors. Halopemid can be used in psychotropic research.

Halopemide

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Purity: 96.57%

Catalog No. T15461Cas No. 59831-65-1

Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2). Halopemid is an antagonist of dopamine receptors. Halopemid can be used in psychotropic research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$29	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$257	In Stock	In Stock
50 mg	$383	In Stock	In Stock
100 mg	$557	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$86	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:96.57%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2). Halopemid is an antagonist of dopamine receptors. Halopemid can be used in psychotropic research.
Targets&IC50	PLD1:220 nM, PLD2:310 nM
In vitro	In transdifferentiated MOVAS cells, Halopemide (1-2 μM; 21 days) influences calcification[1].
In vivo	In the majority of monkeys tested, Halopemide (10 mg/kg; p.o.) causes dyskinesias[2].

Chemical Properties

Molecular Weight	416.88
Formula	C₂₁H₂₂ClFN₄O₂
Cas No.	59831-65-1
Smiles	Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O
Relative Density.	1.337g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (131.93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3988 mL	11.9939 mL	23.9877 mL	119.9386 mL
5 mM	0.4798 mL	2.3988 mL	4.7975 mL	23.9877 mL
10 mM	0.2399 mL	1.1994 mL	2.3988 mL	11.9939 mL
20 mM	0.1199 mL	0.5997 mL	1.1994 mL	5.9969 mL
50 mM	0.0480 mL	0.2399 mL	0.4798 mL	2.3988 mL
100 mM	0.0240 mL	0.1199 mL	0.2399 mL	1.1994 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc