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Drofenine hydrochloride (Synonyms: Hexahydroadiphenine hydrochloride)

Name: Drofenine hydrochloride
Brand: TargetMol
SKU: T0713
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T0713 Copy Product Info

Purity: 99.45%

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Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) is an effective competitive inhibitor of BChE (Ki value: 3 uM).

Drofenine hydrochloride

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Catalog No. T0713

Synonyms Hexahydroadiphenine hydrochloride

Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) is an effective competitive inhibitor of BChE (Ki value: 3 uM).

Cas No. 548-66-3

Pack Size	Price	USA Stock	Global Stock
5 mg	$30	In Stock	In Stock
10 mg	$38	In Stock	In Stock
25 mg	$58	In Stock	In Stock
50 mg	$82	In Stock	In Stock
100 mg	$118	In Stock	In Stock
500 mg	$287	In Stock	-
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.45%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Drofenine hydrochloride AI Summary

Drofenine hydrochloride exhibits a diverse spectrum of bioactivities. It shows potency in numerous assays, including inhibiting ROR gamma transcriptional activity, activating and inhibiting Cytochrome P450 3A4, and delaying death induced by malarial parasite plastid inhibitors. It also inhibits TGF-b, Hepatitis C Virus, ATXN expression, human tyrosyl-DNA phosphodiesterase 1 (TDP1), and GLP-1 Receptor activity as an inverse agonist. Additionally, it induces synthetic lethality in tumor cells producing 2HG and interferes with the binding or entry of Marburg and Ebola viruses into cells. In SARS-CoV-2 related assays, Drofenine hydrochloride shows moderate activity in inhibiting the cell viability of infected Vero E6 cells, with an inhibition index of 0.499. It demonstrates 20.69% inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours and shows antiviral activity by inhibiting the 3CL-Pro protease by 9.639% at 20 µM. The compound also inhibits sodium fluorescein uptake significantly in OATP1B3 and OATP1B1-transfected CHO cells. Moreover, it has a minor effect on Vero E6 cells, inhibiting SARS-CoV-2 induced cytotoxicity by 0.33% at a concentration of 10 µM after 48 hours exposure to the virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) is an effective competitive inhibitor of BChE (Ki value: 3 uM).
Targets&IC50	BChE:3 μM(ki)
Synonyms	Hexahydroadiphenine hydrochloride

Chemical Properties

Molecular Weight	353.93
Formula	C₂₀H₃₁NO₂·HCl
Cas No.	548-66-3
Smiles	Cl.CCN(CC)CCOC(=O)C(C1CCCCC1)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (42.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8254 mL	14.1271 mL	28.2542 mL	141.2709 mL
5 mM	0.5651 mL	2.8254 mL	5.6508 mL	28.2542 mL
10 mM	0.2825 mL	1.4127 mL	2.8254 mL	14.1271 mL
20 mM	0.1413 mL	0.7064 mL	1.4127 mL	7.0635 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc