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18β-Glycyrrhetinic acid

Name: 18β-Glycyrrhetinic acid
Brand: TargetMol
SKU: T0036
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0036Cas No. 471-53-4

Alias Glycyrrhetin, Enoxolone

18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

18β-Glycyrrhetinic acid

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Purity: 99.64%

Catalog No. T0036Alias Glycyrrhetin, EnoxoloneCas No. 471-53-4

18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$29	In Stock	In Stock
5 g	$50	-	In Stock
10 g	$85	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.64%

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
In vitro	MTS assay demonstrates that 24 h treatment of Enoxolone suppresses cell proliferation in both cell lines in a dose-dependent manner. Enoxolone at 160 μM significantly decreases the percentage of viable cells to around 40.5±10.5% in A549 and 38.3±4.6% in NCI-H460 (p<0.01 respectively). When the cells are treated with 320 μM Enoxolone, a greater inhibitory effects on cell proliferation is shown, as the percentage of viable cells is below 30% compare with untreated controls (p<0.001). Treatment with Enoxolone at 160 μM and 320 μM decreases the levels of full-length PARP and increases the levels of cleaved-PARP.
In vivo	Rats in Enoxolone+Triptolide (TP) group which receive low-dose Enoxolone (50?mg/kg) have significant reductions in the three serum parameters when compare with TP rats. Rats in Enoxolone+TP group which receive the high-dose Enoxolone (100?mg/kg) have slightly lowered the levels of three liver enzymes, the reductions do not reach statistical significance compare with TP group. Contrastingly, preadministration of low-dose Enoxolone protects animals from TP-induced hepatic lesions. On the contrary, low-dose Enoxolone (50?mg/kg) markedly suppresses the release of the four cytokines above.
Synonyms	Glycyrrhetin, Enoxolone

Chemical Properties

Molecular Weight	470.68
Formula	C₃₀H₄₆O₄
Cas No.	471-53-4
Smiles	C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](O)CC3)[H])(C(=O)C=C4[C@@]2(C)CC[C@]5(C)[C@]4(C[C@](C(O)=O)(C)CC5)[H])[H]
Relative Density.	0.9967 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 252.5 mg/mL (536.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1246 mL	10.6229 mL	21.2459 mL	106.2293 mL
5 mM	0.4249 mL	2.1246 mL	4.2492 mL	21.2459 mL
10 mM	0.2125 mL	1.0623 mL	2.1246 mL	10.6229 mL
20 mM	0.1062 mL	0.5311 mL	1.0623 mL	5.3115 mL
50 mM	0.0425 mL	0.2125 mL	0.4249 mL	2.1246 mL
100 mM	0.0212 mL	0.1062 mL	0.2125 mL	1.0623 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc