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Vinaxanthone

Name: Vinaxanthone
Brand: TargetMol
SKU: T70955
Price: 326 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T70955Cas No. 133293-89-7

Alias SM-345431

Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that acts as a selective and potent inhibitor of semaphorin3A, phospholipase C (PLC), and FabI, exhibiting antimicrobial activity by blocking intracellular fatty acid synthesis and inhibiting the growth of Staphylococcus aureus.

Vinaxanthone

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Purity: 97.8%

Catalog No. T70955Alias SM-345431Cas No. 133293-89-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$326	In Stock	In Stock
5 mg	$823	In Stock	In Stock
10 mg	$1,350	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:97.8%

Appearance:Solid

Color:White to Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that acts as a selective and potent inhibitor of semaphorin3A, phospholipase C (PLC), and FabI, exhibiting antimicrobial activity by blocking intracellular fatty acid synthesis and inhibiting the growth of Staphylococcus aureus.
Targets&IC50	PA:9.3 μM (mouse colon 26 adenocarcinoma), PA:44 μM (NIH3T3 cell), PA:5.4 μM (Rat brain)
In vitro	Vinaxanthone exhibits selective inhibitory activity against phospholipase C (PLC) in rat brain, mouse colon 26 adenocarcinoma, and mouse fibroblast NIH3T3 cells, with IC50 values of 5.4, 9.3, and 44 μM, respectively.At a concentration of 0.1 mg/mL for 24 hours, Vinaxanthone enhances peripheral nerve regeneration and induces limited neovascularization in the cornea[1].At a concentration of 0.5 μM for 20 minutes, Vinaxanthone may protect against Doxorubicin-induced apoptosis in foot cells[3].In the range of 0.1-1 μM for 24 hours, Vinaxanthone improves the changes in renal tubular cell characteristics induced by TGF-β1[2].
In vivo	Vinaxanthone (SM-345431), administered by subconjunctival injection at a concentration of 0.1 mg/mL every two days for 3 weeks, accelerates peripheral nerve regeneration and functional recovery in a mouse corneal transplantation model[1].Vinaxanthone (SEMA3A-I), given by intraperitoneal injection at a dose of 20 µg, protects against podocyte injury induced by Adriamycin in a mouse model through an anti-apoptotic mechanism[3].
Synonyms	SM-345431

Chemical Properties

Molecular Weight	576.42
Formula	C₂₈H₁₆O₁₄
Cas No.	133293-89-7
Smiles	C(C)(=O)C=1C(=C(C(C)=O)C=C2C1OC=3C(C2=O)=C(C(O)=O)C(O)=C(O)C3)C=4C(=O)C=5C(OC4)=CC(O)=C(O)C5C(O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (138.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7348 mL	8.6742 mL	17.3485 mL	86.7423 mL
5 mM	0.3470 mL	1.7348 mL	3.4697 mL	17.3485 mL
10 mM	0.1735 mL	0.8674 mL	1.7348 mL	8.6742 mL
20 mM	0.0867 mL	0.4337 mL	0.8674 mL	4.3371 mL
50 mM	0.0347 mL	0.1735 mL	0.3470 mL	1.7348 mL
100 mM	0.0173 mL	0.0867 mL	0.1735 mL	0.8674 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc