Anti-UBE2L3 Antibody (5N729) is a Rabbit antibody targeting UBE2L3. Anti-UBE2L3 Antibody (5N729) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.

IgG

5N729

Human,Mouse,Rat

25 ug total protein per lane of various lysates (see on figure) probed with UBE2L3 monoclonal antibody, unconjugated (TMAB-13938) at 1: 1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.

ICC/IF=1:50-200; IF=1:50-200; IHC-Fr=1:100-200; IHC-P=1:100-200; WB=1:500-2000

Monoclonal

A synthesized peptide: human UBE2L3

Human

UBE2L3

Ubiquitin-conjugating enzyme E2 L3

Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.