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Anti-ICOS ligand Antibody (6M734)

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Catalog No. TMAY-01903
Alias LICOS, inducible T-cell co-stimulator ligand, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP-1, B7RP1, B7-h2, B7H2

Anti-ICOS ligand Antibody (6M734) is a Mouse antibody targeting ICOS ligand. Anti-ICOS ligand Antibody (6M734) can be used in ELISA,ELISA(Det).

Anti-ICOS ligand Antibody (6M734)

Anti-ICOS ligand Antibody (6M734)

😃Good
Catalog No. TMAY-01903Alias LICOS, inducible T-cell co-stimulator ligand, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP-1, B7RP1, B7-h2, B7H2
Anti-ICOS ligand Antibody (6M734) is a Mouse antibody targeting ICOS ligand. Anti-ICOS ligand Antibody (6M734) can be used in ELISA,ELISA(Det).
Pack SizePriceAvailabilityQuantity
20 μL$69 7-10 days
100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-ICOS ligand Antibody (6M734) is a Mouse antibody targeting ICOS ligand. Anti-ICOS ligand Antibody (6M734) can be used in ELISA,ELISA(Det).
AliasLICOS, inducible T-cell co-stimulator ligand, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP-1, B7RP1, B7-h2, B7H2
Ig Type
Monoclonal Mouse IgG1
Clone
6M734
Reactivity
Human
Application
ELISA,ELISA(Det)
Recommended Dose
ELISA: 1:1000-1:2000; ELISA(Det): 1:1000-1:10000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICOS Ligand / B7-H2 / ICOSLG (rh ICOS Ligand / B7-H2 / ICOSLG; TMPY-01672; NP_056074.1; Met 1-Ser 258). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundInducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human ICOS Ligand / B7-H2 / ICOSLG protein (TMPY-01672)
Antigen Species
Human
Biology Area
Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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