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Oncrasin-1

Name: Oncrasin-1
Brand: TargetMol
SKU: T8006
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8006Cas No. 75629-57-1

Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations

Oncrasin-1

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Purity: 99.75%

Catalog No. T8006Cas No. 75629-57-1

Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations

Pack Size	Price	Availability
25 mg	$59	In Stock
50 mg	$110	In Stock
100 mg	$203	In Stock
200 mg	$293	In Stock
1 mL x 10 mM (in DMSO)	$65	In Stock

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Batch Information

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Purity:99.75%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations
In vivo	In vivo administration of oncrasin-1 suppressed the growth of K-ras mutant human lung tumor xenografts by >70% and prolonged the survival of nude mice bearing these tumors, without causing detectable toxicity[1].

Chemical Properties

Molecular Weight	269.73
Formula	C₁₆H₁₂ClNO
Cas No.	75629-57-1
Smiles	Clc1ccc(Cn2cc(C=O)c3ccccc23)cc1
Relative Density.	1.21 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 43 mg/mL (159.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7074 mL	18.5371 mL	37.0741 mL	185.3706 mL
5 mM	0.7415 mL	3.7074 mL	7.4148 mL	37.0741 mL
10 mM	0.3707 mL	1.8537 mL	3.7074 mL	18.5371 mL
20 mM	0.1854 mL	0.9269 mL	1.8537 mL	9.2685 mL
50 mM	0.0741 mL	0.3707 mL	0.7415 mL	3.7074 mL
100 mM	0.0371 mL	0.1854 mL	0.3707 mL	1.8537 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc