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Zileuton

Name: Zileuton
Brand: TargetMol
SKU: T0477
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0477Cas No. 111406-87-2

Alias Abbott 64077, A 64077

Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma.

Zileuton

🥰Excellent

Purity: 99.43%

Catalog No. T0477Alias Abbott 64077, A 64077Cas No. 111406-87-2

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$44	In Stock	In Stock
50 mg	$61	In Stock	In Stock
100 mg	$87	In Stock	In Stock
200 mg	$127	In Stock	In Stock
500 mg	$209	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.43%

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COA

Product Introduction

Bioactivity

Description	Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma.
In vitro	Zileuton inhibited PGE2 production in lipopolysaccharide-stimulated human whole blood. In rat carrageenan gum-induced pleurisy, Zileuton decreased PGE2 and 6-ketoprostaglandin F1α pleural levels. In activated mouse peritoneal macrophages and macrophage J774, Zileuton significantly reduced PGE2 and 6-keto prostaglandin F1α levels. In macrophages, Zileuton inhibited PG biosynthesis by interfering with arachidonic acid release.
In vivo	Zileuton inhibited PGE2 production in lipopolysaccharide-stimulated human whole blood. In rat carrageenan gum-induced pleurisy, Zileuton decreased PGE2 and 6-ketoprostaglandin F1α pleural levels. In activated mouse peritoneal macrophages and macrophage J774, Zileuton significantly reduced PGE2 and 6-keto prostaglandin F1α levels. In macrophages, Zileuton inhibited PG biosynthesis by interfering with arachidonic acid release.
Synonyms	Abbott 64077, A 64077

Chemical Properties

Molecular Weight	236.29
Formula	C₁₁H₁₂N₂O₂S
Cas No.	111406-87-2
Smiles	C(N(C(N)=O)O)(C)C1=CC=2C(S1)=CC=CC2
Relative Density.	1.401 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 126 mg/mL (533.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (42.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2321 mL	21.1604 mL	42.3209 mL	211.6044 mL
5 mM	0.8464 mL	4.2321 mL	8.4642 mL	42.3209 mL
10 mM	0.4232 mL	2.1160 mL	4.2321 mL	21.1604 mL
20 mM	0.2116 mL	1.0580 mL	2.1160 mL	10.5802 mL
50 mM	0.0846 mL	0.4232 mL	0.8464 mL	4.2321 mL
100 mM	0.0423 mL	0.2116 mL	0.4232 mL	2.1160 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc