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Suberoyl bis-hydroxamic acid

Name: Suberoyl bis-hydroxamic acid
Brand: TargetMol
SKU: T21505
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21505Cas No. 38937-66-5

Alias Suberohydroxamic acid, SBHA

Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones.

Suberoyl bis-hydroxamic acid

🥰Excellent

Purity: 99.88%

Catalog No. T21505Alias Suberohydroxamic acid, SBHACas No. 38937-66-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	-	In Stock
500 mg	$59	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones.
Targets&IC50	HDAC3:0.3 μm (JK cell), HDAC1:0.25 μm (JK cell)
In vitro	In MEL cells, SBHA leads to the accumulation of acetylated H4, indicating the hydroxamic acid groups are involved in increasing potency and inhibition of HDAC activity. In Jurkat cells, SHBA inhibits the HDAC1 and HDAC3 activities with IC50 value of 0.25 and 0.3 μm respectively.
Synonyms	Suberohydroxamic acid, SBHA

Chemical Properties

Molecular Weight	204.22
Formula	C₈H₁₆N₂O₄
Cas No.	38937-66-5
Smiles	C(CCCCCCC(NO)=O)(NO)=O
Relative Density.	1.219 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 8.16 mg/mL (40 mM), Sonication is recommended.

DMSO: 49 mg/mL (239.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8967 mL	24.4834 mL	48.9668 mL	244.8340 mL
5 mM	0.9793 mL	4.8967 mL	9.7934 mL	48.9668 mL
10 mM	0.4897 mL	2.4483 mL	4.8967 mL	24.4834 mL
20 mM	0.2448 mL	1.2242 mL	2.4483 mL	12.2417 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0979 mL	0.4897 mL	0.9793 mL	4.8967 mL
100 mM	0.0490 mL	0.2448 mL	0.4897 mL	2.4483 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc