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TG003

Name: TG003
Brand: TargetMol
SKU: T60367
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60367Cas No. 719277-26-6

Alias TG 003

TG003 is a potent Clk1/Sty inhibitor that inhibits Clk1 and Clk4, inhibits cancer cell growth and induces apoptosis, and can be used in the study of Duchenne muscular dystrophy.

TG003

🥰Excellent

Purity: 99.46%

Catalog No. T60367Alias TG 003Cas No. 719277-26-6

TG003 is a potent Clk1/Sty inhibitor that inhibits Clk1 and Clk4, inhibits cancer cell growth and induces apoptosis, and can be used in the study of Duchenne muscular dystrophy.

Pack Size	Price	Availability
1 mg	$43	In Stock
5 mg	$98	In Stock
10 mg	$162	In Stock
25 mg	$296	In Stock
50 mg	$489	In Stock
100 mg	$588	In Stock
200 mg	$853	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock

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Batch Information

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Purity:99.46%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	TG003 is a potent Clk1/Sty inhibitor that inhibits Clk1 and Clk4, inhibits cancer cell growth and induces apoptosis, and can be used in the study of Duchenne muscular dystrophy.
Targets&IC50	CLK1/Sty:15–20 nM, CLK4:15–20 nM, CLK2:200 nM
In vitro	The small drug TG003 increases endogenous expression of p53β and p53γ protein isoforms by modulation of TP53 intron 9 alternative splicing. [1] TG003 exhibits the most potent effect on Clk1/Sty and Clk4 (IC50, 15–20 nM) with lesser effect on Clk2 (IC50=200 nM). TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA in vitro by suppression of Clk-mediated phosphorylation. [2]
In vivo	Intrathecal injection of either TG003 (1-100 pM) or IC261 (0.1-1 nM) dose-dependently reduces mechanical allodynia and thermal hyperalgesia induced by carrageenan or CFA. [3]
Synonyms	TG 003

Chemical Properties

Molecular Weight	249.33
Formula	C₁₃H₁₅NO₂S
Cas No.	719277-26-6
Smiles	C(C)N\1C=2C(S/C1=C\C(C)=O)=CC=C(OC)C2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL(401.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0107 mL	20.0537 mL	40.1075 mL	200.5374 mL
5 mM	0.8021 mL	4.0107 mL	8.0215 mL	40.1075 mL
10 mM	0.4011 mL	2.0054 mL	4.0107 mL	20.0537 mL
20 mM	0.2005 mL	1.0027 mL	2.0054 mL	10.0269 mL
50 mM	0.0802 mL	0.4011 mL	0.8021 mL	4.0107 mL
100 mM	0.0401 mL	0.2005 mL	0.4011 mL	2.0054 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc