Shopping Cart

Your shopping cart is currently empty

Berberine sulfate

Name: Berberine sulfate
Brand: TargetMol
SKU: T0461L
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T0461LCas No. 316-41-6

Alias Berberine sulphate, Berberin sulfate, Berberal, AI3-61947

Berberine sulfate (Berberal) is a quaternary ammonium salt of the benzylisoquinoline alkaloid proto-berberines, which can be used in the study of type 2 diabetes mellitus, abdominal obesity and metabolism-related fatty liver disease.

Berberine sulfate

😃Good

Purity: 99.93%

Catalog No. T0461LAlias Berberine sulphate, Berberin sulfate, Berberal, AI3-61947Cas No. 316-41-6

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$40	In Stock	In Stock
500 mg	$64	In Stock	In Stock
1 g	$81	In Stock	In Stock
5 g	$113	-	In Stock
10 g	$168	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.93%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Berberine sulfate (Berberal) is a quaternary ammonium salt of the benzylisoquinoline alkaloid proto-berberines, which can be used in the study of type 2 diabetes mellitus, abdominal obesity and metabolism-related fatty liver disease.
In vitro	Berberine sulfate (1.25-160 μM; 72 h) has a potential inhibitory effect on the proliferation of four colorectal cancer cell lines, LoVo, HCT116, SW480, and HT-29.[5] Berberine suLfate (1.25-160 μM; 24-72 h) induces time- and dose-dependent inhibition of LoVo cell growth.[5] LoVo cells were exposed to Berberine sulfate (10 -80 μM) for 24 hours. Cell cycle analysis of LoVo cells treated with 40 μM berberine by flow cytometry showed an accumulation of cells in the G2/M phase.[5] Berberine sulfate (10 -80 μM) inhibits the expression of cyclin B1, cdc2, and cdc25c proteins after 24 hours, especially at the dose of 80.0 μM.[5]
In vivo	Berberine sulfate (10, 30, or 50 mg/kg/day; gastrointestinal gavage; 10 consecutive days) inhibits the growth of human colorectal adenocarcinoma in vivo. Berberine (30 and 50 mg/kg/d; gastrointestinal gavage) inhibited the growth of human colorectal adenocarcinoma xenografts in nude mice by 33.1% and 45.3%, respectively.[5]
Synonyms	Berberine sulphate, Berberin sulfate, Berberal, AI3-61947

Chemical Properties

Molecular Weight	768.78
Formula	C₄₀H₃₆N₂O₁₂S
Cas No.	316-41-6
Smiles	[O-]S([O-])(=O)=O.COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC.COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 7.69 mg/mL (10 mM), Sonication is recommended.

H2O: 38.46 mg/mL (50.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.3008 mL	6.5038 mL	13.0076 mL	65.0381 mL
5 mM	0.2602 mL	1.3008 mL	2.6015 mL	13.0076 mL
10 mM	0.1301 mL	0.6504 mL	1.3008 mL	6.5038 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0650 mL	0.3252 mL	0.6504 mL	3.2519 mL
50 mM	0.0260 mL	0.1301 mL	0.2602 mL	1.3008 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc