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AHN 1-055 hydrochloride

🥰Excellent

Catalog No. T39429Cas No. 202646-03-5

Alias 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride

AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).

AHN 1-055 hydrochloride

🥰Excellent

Purity: 99.89%

Catalog No. T39429Alias 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochlorideCas No. 202646-03-5

AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$44	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$139	In Stock	In Stock
50 mg	$213	In Stock	In Stock
100 mg	$328	In Stock	In Stock
200 mg	$492	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.89%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) is an inhibitor of dopamine transporter (DAT) and dopamine uptake(IC50 = 71 nM).
Targets&IC50	Dopamine uptake:71 nM
In vivo	In adult male Sprague Dawley rats, AHN 1-055 hydrochloride (5 mg/kg; i.v.) inhibited the uptaking of brain dopamine with an IC50 of 311.8 ng/ml. The Cmax and T1/2 are 1.48 mg/L and 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution[1].
Synonyms	3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride

Chemical Properties

Molecular Weight	379.87
Formula	C₂₁H₂₄ClF₂NO
Cas No.	202646-03-5
Smiles	Cl.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c1ccc(F)cc1)c1ccc(F)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 33.33 mg/mL (87.74 mM), Sonication is recommended.

DMSO: 50 mg/mL (131.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6325 mL	13.1624 mL	26.3248 mL	131.6240 mL
5 mM	0.5265 mL	2.6325 mL	5.2650 mL	26.3248 mL
10 mM	0.2632 mL	1.3162 mL	2.6325 mL	13.1624 mL
20 mM	0.1316 mL	0.6581 mL	1.3162 mL	6.5812 mL
50 mM	0.0526 mL	0.2632 mL	0.5265 mL	2.6325 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0263 mL	0.1316 mL	0.2632 mL	1.3162 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc