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TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)
(Synonyms: ZTNFR9, TRICKB, TRICK2A, TRICK2, TRAILR2, TRAIL receptor 2, TRAIL R2, TNFRSF10B, KILLER/DR5, KILLER, Fas-like protein, DR5TRICK2B, DR5, CD262) Copy Product InfoSynonyms: ZTNFR9, TRICKB, TRICK2A, TRICK2, TRAILR2, TRAIL receptor 2, TRAIL R2, TNFRSF10B, KILLER/DR5, KILLER, Fas-like protein, DR5TRICK2B, DR5, CD262
Catalog No. TMPK-00276 Copy Product Info
DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $43 | 7-10 days | 7-10 days | |
| 10 μg | $66 | 7-10 days | 7-10 days | |
| 20 μg | $105 | 7-10 days | 7-10 days | |
| 50 μg | $197 | 7-10 days | 7-10 days | |
| 100 μg | $336 | 7-10 days | 7-10 days | |
| 200 μg | $596 | 7-10 days | 7-10 days | |
| 500 μg | $1,350 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Human TRAIL R2, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 8.5ng/ml determined by ELISA. |
| Description | DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His-Avi |
| Accession Number | O14763-1 |
| Construction | Ile56-Glu182 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | ZTNFR9, TRICKB, TRICK2A, TRICK2, TRAILR2, TRAIL receptor 2, TRAIL R2, TNFRSF10B, KILLER/DR5, KILLER, Fas-like protein, DR5TRICK2B, DR5, CD262 |
| Research Background |
| Molecular Weight | 17.2 kDa (predicted). Due to glycosylation, the protein migrates to 20-25 kDa based on Tris-Bis PAGE result. |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi) chemical structure | TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi) molecular weight
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