TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)

Catalog No. TMPK-00276

DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)

Catalog No. TMPK-00276

Pack Size	Price	Availability
5 μg	$43	7-10 days
10 μg	$66	7-10 days
20 μg	$105	7-10 days
50 μg	$197	7-10 days
100 μg	$336	7-10 days
200 μg	$596	7-10 days
500 μg	$1,350	7-10 days

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Product Information

Biological Activity	Immobilized Human TRAIL R2, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 8.5ng/ml determined by ELISA.
Description	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Species	Human
Expression System	HEK293 Cells
Tag	C-His-Avi
Accession Number	O14763-1
Synonyms	ZTNFR9,TRICKB,TRICK2A,TRICK2,TRAILR2,TRAIL receptor 2,TRAIL R2,TNFRSF10B,KILLER/DR5,KILLER,Fas-like protein,DR5TRICK2B,DR5,CD262
Construction	Ile56-Glu182
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	17.2 kDa (predicted). Due to glycosylation, the protein migrates to 20-25 kDa based on Tris-Bis PAGE result.
Endotoxin	< 1 EU/μg by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.