Shopping Cart

Remove All
Your shopping cart is currently empty

VU 0365114

Name: VU 0365114
Brand: TargetMol
SKU: T13325
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13325Cas No. 1208222-39-2

VU 0365114 is a positive allosteric modulator of mAChR M5 and increases ACh-induced calcium mobilization(EC50: 2.7 μM).

VU 0365114

🥰Excellent

Purity: 99.86%

Catalog No. T13325Cas No. 1208222-39-2

VU 0365114 is a positive allosteric modulator of mAChR M5 and increases ACh-induced calcium mobilization(EC50: 2.7 μM).

Pack Size	Price	Availability
2 mg	$32	In Stock
5 mg	$53	In Stock
10 mg	$75	In Stock
25 mg	$139	In Stock
50 mg	$235	In Stock
100 mg	$353	In Stock
200 mg	$493	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.86%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	VU 0365114 is a positive allosteric modulator of mAChR M5 and increases ACh-induced calcium mobilization(EC50: 2.7 μM).
Targets&IC50	M5 mAChR:2.7 μM(EC50)

Chemical Properties

Molecular Weight	397.35
Formula	C₂₂H₁₄F₃NO₃
Cas No.	1208222-39-2
Smiles	FC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3ccccc3)C(=O)C(=O)c2c1
Relative Density.	1.386 g/cm3 (Predicted)
Color	Red
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 45 mg/mL (113.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5167 mL	12.5834 mL	25.1667 mL	125.8336 mL
5 mM	0.5033 mL	2.5167 mL	5.0333 mL	25.1667 mL
10 mM	0.2517 mL	1.2583 mL	2.5167 mL	12.5834 mL
20 mM	0.1258 mL	0.6292 mL	1.2583 mL	6.2917 mL
50 mM	0.0503 mL	0.2517 mL	0.5033 mL	2.5167 mL
100 mM	0.0252 mL	0.1258 mL	0.2517 mL	1.2583 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc