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(±)-CPSI-1306

Name: (±)-CPSI-1306
Brand: TargetMol
SKU: T17315
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T17315Cas No. 1309793-47-2

Alias cpsi-1306, 2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one

(±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) is a macrophage migration inhibitory factor (MIF) antagonist and can be used in studies about non-insulin-dependent diabetes mellitus (NIDDM) and the prevention of the deleterious cutaneous effects of acute and chronic UVB exposure.

(±)-CPSI-1306

🥰Excellent

Purity: 97.46%

Catalog No. T17315Alias cpsi-1306, 2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-oneCas No. 1309793-47-2

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$48	In Stock	In Stock
50 mg	$89	In Stock	In Stock
100 mg	$161	In Stock	In Stock
200 mg	$219	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.46%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	(±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) is a macrophage migration inhibitory factor (MIF) antagonist and can be used in studies about non-insulin-dependent diabetes mellitus (NIDDM) and the prevention of the deleterious cutaneous effects of acute and chronic UVB exposure.
In vivo	In mice, (±)-CPSI-1306 decreases their blood glucose levels and can be effective in treating non-insulin-dependent diabetes mellitus (NIDDM) as characterized by high serum levels of glucose and inflammatory cytokine[1]. (±)-CPSI-1306-induced keratinocyte apoptosis is appreciated 30 minutes after a single UVB exposure. (±)-CPSI-1306-treated mice show a significant increase in expression of cleaved caspase-3 at 6, 24, and 48 hours following UVB exposure. (±)-CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation[2].
Synonyms	cpsi-1306, 2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one

Chemical Properties

Molecular Weight	310.3
Formula	C₁₅H₁₆F₂N₂O₃
Cas No.	1309793-47-2
Smiles	Fc1ccc(C2=NOC(CC(=O)N3CCOCC3)C2)c(F)c1
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (145.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (3.22 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2227 mL	16.1134 mL	32.2269 mL	161.1344 mL
5 mM	0.6445 mL	3.2227 mL	6.4454 mL	32.2269 mL
10 mM	0.3223 mL	1.6113 mL	3.2227 mL	16.1134 mL
20 mM	0.1611 mL	0.8057 mL	1.6113 mL	8.0567 mL
50 mM	0.0645 mL	0.3223 mL	0.6445 mL	3.2227 mL
100 mM	0.0322 mL	0.1611 mL	0.3223 mL	1.6113 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc