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Anti-VDAC1 Antibody (5H960)
😃Good
Catalog No. TMAH-01243
Alias YNL2441C, YNL055C, Voltage-dependent anion-selective channel protein 1, Voltage dependent anion selective channel protein 1, Voltage dependent anion channel 1, VDAC-1, VDAC, Porin 31HM, Porin 31HL, POR1, Plasmalemmal porin, Outer mitochondrial membrane protein porin 1, OMP2, N2441, Mitochondrial Porin, MGC111064, hVDAC1
Anti-VDAC1 Antibody (5H960) is an antibody targeting VDAC1. Anti-VDAC1 Antibody (5H960) can be used in ELISA, WB, IHC.
Anti-VDAC1 Antibody (5H960)
Anti-VDAC1 Antibody (5H960)
😃Good
Catalog No. TMAH-01243Alias YNL2441C, YNL055C, Voltage-dependent anion-selective channel protein 1, Voltage dependent anion selective channel protein 1, Voltage dependent anion channel 1, VDAC-1, VDAC, Porin 31HM, Porin 31HL, POR1, Plasmalemmal porin, Outer mitochondrial membrane protein porin 1, OMP2, N2441, Mitochondrial Porin, MGC111064, hVDAC1
Anti-VDAC1 Antibody (5H960) is an antibody targeting VDAC1. Anti-VDAC1 Antibody (5H960) can be used in ELISA, WB, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, WB, IHC Reactivity: Human, Mouse, Rat |
| Alias | YNL2441C, YNL055C, Voltage-dependent anion-selective channel protein 1, Voltage dependent anion selective channel protein 1, Voltage dependent anion channel 1, VDAC-1, VDAC, Porin 31HM, Porin 31HL, POR1, Plasmalemmal porin, Outer mitochondrial membrane protein porin 1, OMP2, N2441, Mitochondrial Porin, MGC111064, hVDAC1 |
| Ig Type | Rabbit IgG |
| Clone | 5H960 |
| Reactivity | Human, Mouse, Rat |
| Verified Activity | 1. Western Blot -Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, 293 whole cell lysate, Jurkat whole cell lysate, HL-60 whole cell lysate, LO2 whole cell lysate, Raji whole cell lysate, Rat heart tissue, Mouse brain tissue -All lanes: VDAC1 antibody at 0.7μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 31 KDa -Observed band size: 31 KDa 2. IHC image of TMAH-01243 diluted at 1:73.125 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. 3. IHC image of TMAH-01243 diluted at 1:73.125 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Application | ELISA, WB, IHC |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. May mediate ATP export from cells. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human VDAC1 |
| Antigen Species | Human |
| Gene ID | 7416 |
| Uniprot ID | |
| Biology Area | Tags & Cell Markers |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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