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VCP/p97 inhibitor-1

Catalog No. T40255 CAS 2630950-38-6

Synonyms: VCP/p97 inhibitor-1

VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degradation process of misfolded polypeptides by the ubiquitin-proteasome system (UPS).

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VCP/p97 inhibitor-1, CAS 2630950-38-6

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25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degradation process of misfolded polypeptides by the ubiquitin-proteasome system (UPS).
Targets&IC50	VCP/p97:54.7 nM
In vitro	VCP/p97 inhibitor-1 (compound 17), administered at 3-fold serial dilutions peaking at 10 μM for a duration of 72 hours, exhibits an anti-proliferative effect on A549 and RPMI8226 cells, with IC50 values of 2.9 μM and 0.86 μM, respectively, as demonstrated in the Cell Viability Assay[1].

Synonyms	VCP/p97 inhibitor-1
Molecular Weight	491.37
Formula	C24H26BN5O4S
CAS No.	2630950-38-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Zhang Y, et al. Discovery of novel pyrimidine molecules containing boronic acid as VCP/p97 Inhibitors. Bioorg Med Chem. 2021;38:116114. 2. van den Boom J, et al. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018;69(2):182-194.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VCP/p97 inhibitor-1 2630950-38-6 VCP/p97 inhibitor 1 VCP/p-97 inhibitor-1 VCP/p97 inhibitor1 inhibitor inhibit

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