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Teriflunomide impurity 3

Name: Teriflunomide impurity 3
Brand: TargetMol
SKU: T9042
Price: 318 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9042Cas No. 1011244-72-6

Alias 4-Amino-N-(4-trifluoromethylphenyl)benzamide

Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 μM and exhibits less activity against COX-2 (IC50 > 100 μM).

Teriflunomide impurity 3

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Purity: 99.62%

Catalog No. T9042Alias 4-Amino-N-(4-trifluoromethylphenyl)benzamideCas No. 1011244-72-6

Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 μM and exhibits less activity against COX-2 (IC50 > 100 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$43	In Stock	In Stock
25 mg	$83	In Stock	In Stock
50 mg	$136	In Stock	In Stock
100 mg	$223	In Stock	In Stock
200 mg	$318	In Stock	In Stock
500 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.62%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Teriflunomide impurity 3 AI Summary

Teriflunomide impurity 3 exhibits selective inhibition of COX1 over COX2, achieving an inhibition of 71.0% at a concentration of 100 µM for COX1 and only 14.0% for COX2. The compound has a higher potency for inhibiting COX1, with an IC50 value of 30,000 nM, compared to its effect on COX2, where the IC50 value exceeds 100,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 μM and exhibits less activity against COX-2 (IC50 > 100 μM).
Targets&IC50	COX-1:30 μM, COX-2:>100 µM
Synonyms	4-Amino-N-(4-trifluoromethylphenyl)benzamide

Chemical Properties

Molecular Weight	280.25
Formula	C₁₄H₁₁F₃N₂O
Cas No.	1011244-72-6
Smiles	Nc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F
Relative Density.	1.373 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (892.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (11.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5682 mL	17.8412 mL	35.6824 mL	178.4121 mL
5 mM	0.7136 mL	3.5682 mL	7.1365 mL	35.6824 mL
10 mM	0.3568 mL	1.7841 mL	3.5682 mL	17.8412 mL
20 mM	0.1784 mL	0.8921 mL	1.7841 mL	8.9206 mL
50 mM	0.0714 mL	0.3568 mL	0.7136 mL	3.5682 mL
100 mM	0.0357 mL	0.1784 mL	0.3568 mL	1.7841 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc