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LY 456236 hydrochloride

🥰Excellent
Catalog No. T22954Cas No. 338736-46-2
Alias MPMQ hydrochloride

LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM.

LY 456236 hydrochloride

LY 456236 hydrochloride

🥰Excellent
Purity: 99.95%
Catalog No. T22954Alias MPMQ hydrochlorideCas No. 338736-46-2
LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM.
Pack SizePriceAvailabilityQuantity
5 mg$34In Stock
10 mg$54In Stock
25 mg$117In Stock
50 mg$191In Stock
100 mg$275In Stock
200 mg$383In Stock
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Purity:99.95%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM.
Targets&IC50
EGFR:0.91 μM, mGlu1:0.145 μM
In vitro
LY456236 (2 μM; 30 min) reduces the proliferation of DHPG-stimulated OCCM-30 cells.[1]
In vivo
LY456236 exhibits anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once).[2]
SynonymsMPMQ hydrochloride
Chemical Properties
Molecular Weight317.77
FormulaC16H16ClN3O2
Cas No.338736-46-2
SmilesCl.COc1ccc(Nc2ncnc3ccc(OC)cc23)cc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 225.0 mg/mL (708.1 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1469 mL15.7347 mL31.4693 mL157.3465 mL
5 mM0.6294 mL3.1469 mL6.2939 mL31.4693 mL
10 mM0.3147 mL1.5735 mL3.1469 mL15.7347 mL
20 mM0.1573 mL0.7867 mL1.5735 mL7.8673 mL
50 mM0.0629 mL0.3147 mL0.6294 mL3.1469 mL
100 mM0.0315 mL0.1573 mL0.3147 mL1.5735 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

MPMQ HydrochloridemGluRLY-456236 HydrochlorideLY456236 HydrochlorideLY 456236 HydrochlorideEGFR
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