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LY 456236 hydrochloride

Name: LY 456236 hydrochloride
Brand: TargetMol
SKU: T22954
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22954Cas No. 338736-46-2

Alias MPMQ hydrochloride

LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM.

LY 456236 hydrochloride

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Purity: 99.95%

Catalog No. T22954Alias MPMQ hydrochlorideCas No. 338736-46-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	In Stock	In Stock
10 mg	$54	In Stock	In Stock
25 mg	$117	In Stock	In Stock
50 mg	$191	In Stock	In Stock
100 mg	$275	In Stock	In Stock
200 mg	$383	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	LY 456236 hydrochloride (MPMQ hydrochloride) is an mGlu1 receptor antagonist with an ic50 value of 143 nM. LY456236 has selective, non-competitive and oral activity, and can inhibit the hydrolysis of inositol phosphate with IC50 of 0.145 μM. LY 456236 hydrochloride inhibited EGFR with IC50 of 0.91 μM.
Targets&IC50	EGFR:0.91 μM, mGlu1:0.145 μM
In vitro	LY456236 (2 μM; 30 min) reduces the proliferation of DHPG-stimulated OCCM-30 cells.[1]
In vivo	LY456236 exhibits anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once).[2]
Synonyms	MPMQ hydrochloride

Chemical Properties

Molecular Weight	317.77
Formula	C₁₆H₁₆ClN₃O₂
Cas No.	338736-46-2
Smiles	Cl.COc1ccc(Nc2ncnc3ccc(OC)cc23)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (708.06 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1469 mL	15.7347 mL	31.4693 mL	157.3465 mL
5 mM	0.6294 mL	3.1469 mL	6.2939 mL	31.4693 mL
10 mM	0.3147 mL	1.5735 mL	3.1469 mL	15.7347 mL
20 mM	0.1573 mL	0.7867 mL	1.5735 mL	7.8673 mL
50 mM	0.0629 mL	0.3147 mL	0.6294 mL	3.1469 mL
100 mM	0.0315 mL	0.1573 mL	0.3147 mL	1.5735 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc