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Anti-CD33 Monoclonal Antibody-Biotin
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Catalog No. TMAZ-0119B
Alias Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67
Anti-CD33 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody-Biotin can be used in ELISA,FCM,IF.
Anti-CD33 Monoclonal Antibody-Biotin
Anti-CD33 Monoclonal Antibody-Biotin
😃Good
Catalog No. TMAZ-0119BAlias Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67
Anti-CD33 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody-Biotin can be used in ELISA,FCM,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μg | $109 | 12 days | 12 days | |
| 50 μg | $131 | 12 days | 12 days | |
| 100 μg | $183 | 12 days | 12 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD33 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CD33. Anti-CD33 Monoclonal Antibody-Biotin can be used in ELISA,FCM,IF. |
| Synonyms | Sialic acid-binding Ig-like lectin 3, Myeloid cell surface antigen CD33, gp67 |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of CD33 overexpressed 340F cells with TMAZ-0119B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD33 protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in PBS. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed: 10611343, PubMed: 11320212, PubMed: 15597323). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed: 7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed: 10887109, PubMed: 28325905). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed: 10206955, PubMed: 10556798, PubMed: 10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed: 10206955, PubMed: 10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed: 15597323) |
| Conjucates | Biotin |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | CD33 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer Research |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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