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ACHN-975 TFA

Name: ACHN-975 TFA
Brand: TargetMol
SKU: T10236
Price: 299 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10236Cas No. 1410809-37-8

Alias ACHN975 TFA

ACHN-975 TFA is a selective inhibitor of the bacterial enzyme LpxC with nM-level activity. It exhibits antimicrobial activity with MIC values below 1 μg/mL against multiple Gram-negative bacteria.

ACHN-975 TFA

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Purity: 99.57%

Catalog No. T10236Alias ACHN975 TFACas No. 1410809-37-8

ACHN-975 TFA is a selective inhibitor of the bacterial enzyme LpxC with nM-level activity. It exhibits antimicrobial activity with MIC values below 1 μg/mL against multiple Gram-negative bacteria.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$299	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.57%

Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	ACHN-975 TFA is a selective inhibitor of the bacterial enzyme LpxC with nM-level activity. It exhibits antimicrobial activity with MIC values below 1 μg/mL against multiple Gram-negative bacteria.
Targets&IC50	LpxC:
In vitro	ACHN-975 TFA demonstrated potent inhibitory activity against all tested Pseudomonas aeruginosa isolates, with MIC50 and MIC90 values of 0.06 and 0.25 μg/ml, respectively [2].
In vivo	In the neutropenic murine thigh infection model, ACHN-975 TFA at doses of 10 mg/kg and 30 mg/kg significantly reduced bacterial counts within 4 hours and maintained them below the detection limit for 24 hours [2].
Animal Research	Animal Model: Neutropenic mouse thigh model with P. aeruginosa ATCC 27853. Dosage: 5-30 mg/kg. Administration: i.p.; single dose [2]
Synonyms	ACHN975 TFA

Chemical Properties

Molecular Weight	483.44
Formula	C₂₂H₂₄F₃N₃O₆
Cas No.	1410809-37-8
Smiles	C(C(O)=O)(F)(F)F.C(#CC#CC1=CC=C(C(N[C@H](C(NO)=O)C(C)(C)N)=O)C=C1)[C@H]2[C@H](CO)C2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (165.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0685 mL	10.3425 mL	20.6851 mL	103.4255 mL
5 mM	0.4137 mL	2.0685 mL	4.1370 mL	20.6851 mL
10 mM	0.2069 mL	1.0343 mL	2.0685 mL	10.3425 mL
20 mM	0.1034 mL	0.5171 mL	1.0343 mL	5.1713 mL
50 mM	0.0414 mL	0.2069 mL	0.4137 mL	2.0685 mL
100 mM	0.0207 mL	0.1034 mL	0.2069 mL	1.0343 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc