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ACHN-975 TFA

Name: ACHN-975 TFA
Brand: TargetMol
SKU: T10236
Rating: 4.5 (1 reviews)

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Catalog No. T10236Cas No. 1410809-37-8

Alias ACHN975 TFA

ACHN-975 TFA is a selective inhibitor of the bacterial enzyme LpxC with nM-level activity. It exhibits antimicrobial activity with MIC values below 1 μg/mL against multiple Gram-negative bacteria.

ACHN-975 TFA

😃Good

Catalog No. T10236Alias ACHN975 TFACas No. 1410809-37-8

ACHN-975 TFA is a selective inhibitor of the bacterial enzyme LpxC with nM-level activity. It exhibits antimicrobial activity with MIC values below 1 μg/mL against multiple Gram-negative bacteria.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,100	10-14 weeks	10-14 weeks
50 mg	$1,430	10-14 weeks	10-14 weeks
100 mg	$2,170	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	ACHN-975 TFA is a selective inhibitor of the bacterial enzyme LpxC with nM-level activity. It exhibits antimicrobial activity with MIC values below 1 μg/mL against multiple Gram-negative bacteria.
Targets&IC50	LpxC:
In vitro	ACHN-975 TFA demonstrated potent inhibitory activity against all tested Pseudomonas aeruginosa isolates, with MIC50 and MIC90 values of 0.06 and 0.25 μg/ml, respectively [2].
In vivo	In the neutropenic murine thigh infection model, ACHN-975 TFA at doses of 10 mg/kg and 30 mg/kg significantly reduced bacterial counts within 4 hours and maintained them below the detection limit for 24 hours [2].
Animal Research	Animal Model: Neutropenic mouse thigh model with P. aeruginosa ATCC 27853. Dosage: 5-30 mg/kg. Administration: i.p.; single dose [2]
Synonyms	ACHN975 TFA

Chemical Properties

Molecular Weight	483.44
Formula	C₂₂H₂₄F₃N₃O₆
Cas No.	1410809-37-8
Smiles	C(C(O)=O)(F)(F)F.C(#CC#CC1=CC=C(C(N[C@H](C(NO)=O)C(C)(C)N)=O)C=C1)[C@H]2[C@H](CO)C2
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (165.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0685 mL	10.3425 mL	20.6851 mL	103.4255 mL
5 mM	0.4137 mL	2.0685 mL	4.1370 mL	20.6851 mL
10 mM	0.2069 mL	1.0343 mL	2.0685 mL	10.3425 mL
20 mM	0.1034 mL	0.5171 mL	1.0343 mL	5.1713 mL
50 mM	0.0414 mL	0.2069 mL	0.4137 mL	2.0685 mL
100 mM	0.0207 mL	0.1034 mL	0.2069 mL	1.0343 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc