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Orelabrutinib

Name: Orelabrutinib
Brand: TargetMol
SKU: T12317
Price: 83 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12317Cas No. 1655504-04-3

Alias ICP-022

Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).

Orelabrutinib

🥰Excellent

Purity: 99.54%

Catalog No. T12317Alias ICP-022Cas No. 1655504-04-3

Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).

Pack Size	Price	Availability
1 mg	$83	In Stock
5 mg	$197	In Stock
10 mg	$332	In Stock
25 mg	$547	In Stock
50 mg	$758	In Stock
100 mg	$996	In Stock
500 mg	$1,990	In Stock
1 mL x 10 mM (in DMSO)	$228	In Stock

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Purity:99.54%

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COA LCMS

Product Introduction

Bioactivity

Description	Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).
Synonyms	ICP-022

Chemical Properties

Molecular Weight	427.49
Formula	C₂₆H₂₅N₃O₃
Cas No.	1655504-04-3
Smiles	NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
Relative Density.	1.213 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (128.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3392 mL	11.6962 mL	23.3924 mL	116.9618 mL
5 mM	0.4678 mL	2.3392 mL	4.6785 mL	23.3924 mL
10 mM	0.2339 mL	1.1696 mL	2.3392 mL	11.6962 mL
20 mM	0.1170 mL	0.5848 mL	1.1696 mL	5.8481 mL
50 mM	0.0468 mL	0.2339 mL	0.4678 mL	2.3392 mL
100 mM	0.0234 mL	0.1170 mL	0.2339 mL	1.1696 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc