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Orelabrutinib

Name: Orelabrutinib
Brand: TargetMol
SKU: T12317
Price: 83 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12317Cas No. 1655504-04-3

Alias ICP-022

Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).

Orelabrutinib

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Purity: 99.54%

Catalog No. T12317Alias ICP-022Cas No. 1655504-04-3

Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$83	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$332	In Stock	In Stock
25 mg	$547	In Stock	In Stock
50 mg	$758	In Stock	In Stock
100 mg	$996	In Stock	In Stock
500 mg	$1,990	-	In Stock
1 mL x 10 mM (in DMSO)	$228	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.54%

Color:White

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COA LCMS HNMR

Product Introduction

Orelabrutinib AI Summary

Orelabrutinib irreversibly inhibits BTK with an IC50 value of 1.6 nM. It demonstrates bioactivity by inhibiting protein phosphorylation across various cell types. In human Ramos cells, it inhibits the phosphorylation of BTK at the Tyr 223 residue with an IC50 value of 20.0 nM. Additionally, Orelabrutinib inhibits EGFR autophosphorylation at the Tyr 1068 residue in EGFR-amplified human A-431 cells with an IC50 value of 5900.0 nM. In HEK293 cells, it inhibits FLAG-tagged TEC autophosphorylation with an IC50 value of 37.2 nM. These findings highlight its specificity and selectivity for certain protein kinases..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).
Synonyms	ICP-022

Chemical Properties

Molecular Weight	427.49
Formula	C₂₆H₂₅N₃O₃
Cas No.	1655504-04-3
Smiles	NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
Relative Density.	1.213 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (128.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3392 mL	11.6962 mL	23.3924 mL	116.9618 mL
5 mM	0.4678 mL	2.3392 mL	4.6785 mL	23.3924 mL
10 mM	0.2339 mL	1.1696 mL	2.3392 mL	11.6962 mL
20 mM	0.1170 mL	0.5848 mL	1.1696 mL	5.8481 mL
50 mM	0.0468 mL	0.2339 mL	0.4678 mL	2.3392 mL
100 mM	0.0234 mL	0.1170 mL	0.2339 mL	1.1696 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc