Shopping Cart

Your shopping cart is currently empty

Myricetin

Name: Myricetin
Brand: TargetMol
SKU: T0579
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T0579Cas No. 529-44-2

Alias Cannabiscetin

Myricetin (Cannabiscetin) is a natural flavonoid and MEK1 inhibitor. Myricetin has hypoglycemic, antioxidant, hepatoprotective, anti-tumor and anti-inflammatory activities.

Myricetin

Copy Product Info

🥰Excellent

Purity: 99.85%

Catalog No. T0579Alias CannabiscetinCas No. 529-44-2

Myricetin (Cannabiscetin) is a natural flavonoid and MEK1 inhibitor. Myricetin has hypoglycemic, antioxidant, hepatoprotective, anti-tumor and anti-inflammatory activities.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$39	In Stock	In Stock
100 mg	$54	In Stock	In Stock
500 mg	$125	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.85%

Color:Yellow

Resource Download

COA

Product Introduction

Bioactivity

Description	Myricetin (Cannabiscetin) is a natural flavonoid and MEK1 inhibitor. Myricetin has hypoglycemic, antioxidant, hepatoprotective, anti-tumor and anti-inflammatory activities.
Targets&IC50	HepG2 cells:> 20 μM, Jurkat cells:10 μM, BV-2 cells:> 100 μM, CWR22R:13.1 μM, SKBR3 cells:13.5 μM, H9 cells:69 μM, MCF-7 cells:4.7 mg/mL, PI3Kγ:0.17 μM (Kd), HCT116 cells:23 μM, HEK293 cells:> 10 μM, A549 cells:14.8 mg/mL
In vitro	METHODS: Human hepatocellular carcinoma cells HepG2 and Huh-7 were treated with Myricetin (100-200 µM) for 72 h. Cell viability was measured by CCK-8 assay. RESULTS: Myricetin significantly inhibited cell growth in a dose-dependent manner. [1] METHODS: Ovarian cancer cells A2780 and OVCAR3 were treated with Myricetin (25 µM) for 48 h. Apoptosis was detected by single stranded-DNA Apoptosis ELISA kit. RESULTS: In A2780 cells treated with Myricetin, an approximately 2.5-fold increase in apoptotic signaling was observed compared to untreated cells, whereas under similar treatment conditions, apoptotic signaling in OVCAR3 cells increased approximately 4-fold compared to untreated cells. [2]
In vivo	METHODS: To detect anti-tumor activity in vivo, Myricetin (30 mg/kg once a day) and cisplatin (5 mg/kg every three days) were intraperitoneally injected into BALB/c nude mice bearing Huh-7 xenografts for two weeks. RESULTS: Treatment with Myricetin or cisplatin alone moderately inhibited tumor growth, but the combination treatment inhibited tumor growth more significantly than Myricetin or cisplatin alone. [1]
Cell Research	Pancreatic cancer cells (MIA PaCa-2, Panc-1 or S2-013) or normal pancreatic ductal cells (PDCs) are treated with myricetin (12.5–200 μM). Cell viability is determined using the Dojindo Cell Counting Kit-8. Cells are seeded onto a 96-well plate at 1×104 cells per well and allowed to adhere overnight. After treatment with myricetin at various concentrations for 24 hours, 10 μL of the tetrazolium substrate is added to each well of the plate. Plates are incubated at 37°C for 1 hour, after which the absorbance at 450 nm is measured[2].
Synonyms	Cannabiscetin

Chemical Properties

Molecular Weight	318.24
Formula	C₁₅H₁₀O₈
Cas No.	529-44-2
Smiles	O=C1C=2C(OC(=C1O)C3=CC(O)=C(O)C(O)=C3)=CC(O)=CC2O
Relative Density.	1.4222 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 20 mg/mL (62.85 mM), Heating is recommended.

DMSO: 55 mg/mL (172.83 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 6.3 mg/mL (19.8 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1423 mL	15.7114 mL	31.4228 mL	157.1141 mL
5 mM	0.6285 mL	3.1423 mL	6.2846 mL	31.4228 mL
10 mM	0.3142 mL	1.5711 mL	3.1423 mL	15.7114 mL
20 mM	0.1571 mL	0.7856 mL	1.5711 mL	7.8557 mL
50 mM	0.0628 mL	0.3142 mL	0.6285 mL	3.1423 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0314 mL	0.1571 mL	0.3142 mL	1.5711 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc