L-Erythrulose (L-glycero-Tetrulose) is a ketose extracted from sugar cane that has tanning and moisturizing effects and is often added to skin care products.

b>METHODS: Numerous toxicity and metabolism studies were conducted on erythritol in rats, mice, and dogs; toxicity studies included long-term feeding studies to determine carcinogenic potential, intravenous and oral teratogenicity studies to determine possible effects on the fetus, oral studies of erythritol to determine the possibility of reproductive effects, and bacterial and mammalian systemic studies to determine mutagenic potential.
RESULTS: Metabolism studies in animals showed that erythritol was almost completely absorbed, rather than systemically metabolized, and excreted unchanged in the urine; safety studies showed that erythritol was well tolerated and did not cause toxicological effects; clinical studies showed that erythritol was well tolerated and did not cause any toxicologically relevant effects even after high-dose exposure; erythritol administered orally to the human body was rapidly absorbed from the gastrointestinal tract and quantitatively excreted in the urine without metabolic changes; there was no evidence of toxicity from erythritol. [1]