BMPR1A/ALK-3 Protein, Human, Recombinant (hFc)

Name: BMPR1A/ALK-3 Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-05485
Rating: 4.5 (1 reviews)

(Synonyms: SKR5, CD292, bone morphogenetic protein receptor, type IA, ALK3, ACVRLK3, 10q23del) Copy Product Info

Synonyms: SKR5, CD292, bone morphogenetic protein receptor, type IA, ALK3, ACVRLK3, 10q23del

Catalog No. TMPY-05485 Copy Product Info

BMPR1A/ALK-3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.13 kDa and the accession number is P36894.

Pack Size	Price	USA Stock	Global Stock
5 µg	$48	7-10 days	7-10 days
10 µg	$76	7-10 days	7-10 days
20 µg	$118	7-10 days	7-10 days
50 µg	$237	7-10 days	7-10 days
100 µg	$458	7-10 days	7-10 days
200 µg	$737	7-10 days	7-10 days
500 µg	$1,930	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Measured by its ability to inhibit rhBMP4-induced alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is typically 0.1-0.4 μg/mL in the presence of 15 ng/mL of recombinant human BMP4. (QC Test)
Description	BMPR1A/ALK-3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.13 kDa and the accession number is P36894.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc (IgG1)
Accession Number	P36894
Construction	Gln24-Arg152
Protein Purity	> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	SKR5, CD292, bone morphogenetic protein receptor, type IA, ALK3, ACVRLK3, 10q23del
Research Background	Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. The BMP receptors form a subfamily of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. ALK-3/BMPR1A is expressed in the epithelium during branching morphogenesis. Deletion of BMPR1A in the epithelium with an Sftpc-cre transgene leads to dramatic defects in lung development. ALK-3 and ALK-6 share a high degree of homology, yet possess distinct signaling roles. The transforming growth factor (TGF)-beta type III receptor (TbetaRIII) enhanced both ALK-3 and ALK-6 signaling. TbetaRIII associated with ALK-3 primarily through their extracellular domains, whereas its interaction with ALK-6 required both the extracellular and cytoplasmic domains. ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. Cardiac muscle lacking ALK-3 was specifically deficient in expressing TGFbeta2, an established paracrine mediator of cushion morphogenesis. Hence, ALK-3 is essential, beyond just the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis.

Chemical Properties

Molecular Weight

40.13 kDa (predicted), 50-60 kDa (due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.