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Anti-RGMA Antibody (7L596)
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Catalog No. TMAB-12222
Anti-RGMA Antibody (7L596) is a Rabbit antibody targeting RGMA. Anti-RGMA Antibody (7L596) can be used in ICC/IF.
Anti-RGMA Antibody (7L596)
Anti-RGMA Antibody (7L596)
😃Good
Catalog No. TMAB-12222
Anti-RGMA Antibody (7L596) is a Rabbit antibody targeting RGMA. Anti-RGMA Antibody (7L596) can be used in ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-RGMA Antibody (7L596) is a Rabbit antibody targeting RGMA. Anti-RGMA Antibody (7L596) can be used in ICC/IF. |
| Ig Type | IgG |
| Clone | 7L596 |
| Reactivity | (predicted:Human,Mouse,Rat) |
| Application | |
| Recommended Dose | ICC/IF=1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Lipid-anchor, GPI-anchor |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. |
| Immunogen | A synthesized peptide: human Repulsive guidance molecule A |
| Antigen Species | Human |
| Gene Name | RGMA |
| Gene ID | |
| Protein Name | Repulsive guidance molecule A |
| Uniprot ID | |
| Function | Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. |
| Molecular Weight | Theoretical: 49 kDa. Actual: 37 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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